Regulation of TLR expression, a new perspective for the role of VIP in immunity

被引：36

作者：

Gomariz, R. P.

Arranz, A.

Juarranz, Y.

Gutierrez-Canas, I.

Garcia-Gomez, M.

Leceta, J.

Martinez, C.

机构：

[1] Univ Complutense, Fac Biol, Dept Cell Biol, E-28040 Madrid, Spain

[2] Univ Complutense, Fac Med, E-28040 Madrid, Spain

来源：

PEPTIDES | 2007年 / 28卷 / 09期

关键词：

neuroimmunomodulation; vasoactive intestinal peptide; toll-like receptors;

D O I：

10.1016/j.peptides.2007.07.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The contribution of VIP immune functions to the regulation of homeostasis and health is well known. Modulation of immune responses through new therapeutics is one of the main goals of physicians and scientists seeking to control inflammatory/autoimmune diseases in humans. Initial therapeutic strategies targeted adaptive immune responses; discovery of Toll-like receptors (TLR) has widened the horizon to include targeting the innate immune system. In this review we have summarized recent information about VIP modulation of TLR function, and we suggest that VIP represents a new therapeutic option in the management of several pathologies. (C) 2007 Elsevier Inc. All rights reserved.

引用

收藏

页码：1825 / 1832

页数：8

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