Regulation of TLR expression, a new perspective for the role of VIP in immunity

被引：36

作者：

Gomariz, R. P.

Arranz, A.

Juarranz, Y.

Gutierrez-Canas, I.

Garcia-Gomez, M.

Leceta, J.

Martinez, C.

机构：

[1] Univ Complutense, Fac Biol, Dept Cell Biol, E-28040 Madrid, Spain

[2] Univ Complutense, Fac Med, E-28040 Madrid, Spain

来源：

PEPTIDES | 2007年 / 28卷 / 09期

关键词：

neuroimmunomodulation; vasoactive intestinal peptide; toll-like receptors;

D O I：

10.1016/j.peptides.2007.07.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The contribution of VIP immune functions to the regulation of homeostasis and health is well known. Modulation of immune responses through new therapeutics is one of the main goals of physicians and scientists seeking to control inflammatory/autoimmune diseases in humans. Initial therapeutic strategies targeted adaptive immune responses; discovery of Toll-like receptors (TLR) has widened the horizon to include targeting the innate immune system. In this review we have summarized recent information about VIP modulation of TLR function, and we suggest that VIP represents a new therapeutic option in the management of several pathologies. (C) 2007 Elsevier Inc. All rights reserved.

引用

收藏

页码：1825 / 1832

页数：8

相关论文

共 66 条

[41] TLR9 signals after translocating from the ER to CpG DNA in the lysosome [J].

Latz, E ;

Schoenemeyer, A ;

Visintin, A ;

Fitzgerald, KA ;

Monks, BG ;

Knetter, CF ;

Lien, E ;

Nilsen, NJ ;

Espevik, T ;

Golenbock, DT .

NATURE IMMUNOLOGY, 2004, 5 (02) :190-198

[42] LYMPHOID-CELL SUBPOPULATIONS CONTAINING VASOACTIVE-INTESTINAL-PEPTIDE IN THE RAT [J].

LECETA, J ;

MARTINEZ, MC ;

DELGADO, M ;

GARRIDO, E ;

GOMARIZ, RP .

PEPTIDES, 1994, 15 (05) :791-797

[43] TLR9 Is localized in the endoplasmic reticulum prior to stimulation [J].

Leifer, CA ;

Kennedy, MN ;

Mazzoni, A ;

Lee, CW ;

Kruhlak, MJ ;

Segal, DA .

JOURNAL OF IMMUNOLOGY, 2004, 173 (02) :1179-1183

[44] The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults [J].

Lemaitre, B ;

Nicolas, E ;

Michaut, L ;

Reichhart, JM ;

Hoffmann, JA .

CELL, 1996, 86 (06) :973-983

[45] Regulation of VIP production and secretion by murine lymphocytes [J].

Martinez, C ;

Delgado, M ;

Abad, C ;

Gomariz, RP ;

Ganea, D ;

Leceta, J .

JOURNAL OF NEUROIMMUNOLOGY, 1999, 93 (1-2) :126-138

[46] Subcellular localization of toll-like receptor 3 in human dendritic cells [J].

Matsumoto, M ;

Funami, K ;

Tanabe, M ;

Oshiumi, H ;

Shingai, M ;

Seto, Y ;

Yamamoto, A ;

Seya, T .

JOURNAL OF IMMUNOLOGY, 2003, 171 (06) :3154-3162

[47] Aberrant toll receptor expression and endotoxin hypersensitivity in mice lacking a functional TGF-β1 signaling pathway [J].

McCartney-Francis, N ;

Jin, WW ;

Wahl, SM .

JOURNAL OF IMMUNOLOGY, 2004, 172 (06) :3814-3821

[48] Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells [J].

Miller, YI ;

Viriyakosol, S ;

Binder, CJ ;

Feramisco, JR ;

Kirkland, TN ;

Witztum, JL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (03) :1561-1568

[49] Transforming growth factor-β differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide-induced TLR4 signaling [J].

Naiki, Y ;

Michelsent, KS ;

Zhang, WX ;

Chen, SA ;

Doherty, TM ;

Arditi, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (07) :5491-5495

[50] Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells [J].

Netea, MG ;

Sutmuller, R ;

Hermann, C ;

Van der Graaf, CAA ;

Van der Meer, JWM ;

van Krieken, JH ;

Hartung, T ;

Adema, G ;

Kullberg, BJ .

JOURNAL OF IMMUNOLOGY, 2004, 172 (06) :3712-3718

← 1 2 3 4 5 6 7 →