Effects of the total flavonoid extract of Xiaobuxin-Tang on depression-like behavior induced by lipopolysaccharide and proinflammatory cytokine levels in mice

被引:22
作者
An, Lei [1 ,2 ]
Li, Jing [2 ,3 ]
Yu, Song-Tao [4 ]
Xue, Rui [2 ]
Yu, Neng-Jiang [2 ]
Chen, Hong-Xia [2 ]
Zhang, Li-Ming [2 ]
Zhao, Nan [2 ]
Li, Yun-Feng [2 ]
Zhang, You-Zhi [2 ]
机构
[1] Beijing Technol & Business Univ, Sch Food & Chem Engn, Beijing 100048, Peoples R China
[2] Acad Mil Med Sci, Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China
[3] Dalian Municipal Friendship Hosp, Dept Pharm, Dalian 116100, Peoples R China
[4] Northwestern Univ, Dept Pediat, Childrens Mem Res Ctr, Feinberg Sch Med, Chicago, IL 60611 USA
基金
中国国家自然科学基金;
关键词
Antidepressant; XBXT-2; Inflammation; Cytokine; NECROSIS-FACTOR-ALPHA; HIPPOCAMPAL NEUROGENESIS; ANTIDEPRESSANT ACTIVITY; INFLAMMATORY CYTOKINES; EXPRESSION; PROLIFERATION; CONSTITUENTS; METAANALYSIS; INVOLVEMENT; BLOCKADE;
D O I
10.1016/j.jep.2015.01.022
中图分类号
Q94 [植物学];
学科分类号
071001 [植物学];
摘要
Ethnopharmacological relevance: Xiaobuxin-Tang (XBXT), a traditional Chinese herbal decoction, has been used for the treatment of depressive disorders from ancient clinic. The aim of the study was to explore the involvement of inflammation or inflammatory markers in the antidepressant-like effects of XBXT-2. Materials and methods: Depression-like behavior was induced by lipopolysaccharide (LPS, 0.2 mg/kg, i.p) in tail suspension test (TST) and forced swimming test (FST) in mice. The effects of the total flavonoids (XBXT-2) extracted from XBXT (25, 50, and 100 mg/kg, p.o.) and duloxetine (DLX, 10 mg/kg, p.o.) on the immobility time in TST and FST were determined 24 h after LPS pretreatment. The locomotor activity was also determined to eliminate the false-positive activity. Additionally, in order to further evaluate the effect of XBXT-2 on inflammation, the levels of brain proinflammatory cytokines including IL-1 beta and TNF-alpha were assessed by ELISA. Results: The pretreatment with LPS significantly increased the immobility time in TST and FST in mice, as well as the brain levels of IL-1 beta and TNF-alpha. XBXT-2 (25, 50, and 100 mg/kg, p.o.) administration decreased the duration of immobility in TST and FST, and normalized the cytokines levels. The positive control DLX (10 mg/kg, p.o.) exerted similar effects. Meanwhile, neither LPS pretreatment nor drugs treatment had any effect on mouse locomotor activity. Conclusions: These results suggest that inflammation and inflammatory cytokines may be involved in the antidepressant-like effects of XBXT-2. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:83 / 87
页数:5
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