Serum Clusterin Levels Are Not Increased in Presymptomatic Alzheimer's Disease

被引：44

作者：

Ijsselstijn, Linda ^{[1
]}

Dekker, Lennard J. M. ^{[1
]}

Koudstaal, Peter J. ^{[1
]}

Hofman, Albert ^{[2
]}

Smitt, Peter A. E. Sillevis ^{[1
]}

Breteer, Monique M. B. ^{[2
]}

Luider, Theo M. ^{[1
]}

机构：

[1] Erasmus MC, Dept Neurol, NL-3000 CA Rotterdam, Netherlands

[2] Erasmus MC, Dept Epidemiol, NL-3000 CA Rotterdam, Netherlands

来源：

JOURNAL OF PROTEOME RESEARCH | 2011年 / 10卷 / 04期

关键词：

clusterin; Alzheimer's disease; presymptomatic; MRM assay; serum; GENOME-WIDE ASSOCIATION; AMYLOID-BETA; IDENTIFIES VARIANTS; APOLIPOPROTEIN-J; PLASMA; ASSAY; PROTEOMICS; DEMENTIA; SP-40,40; LESIONS;

D O I：

10.1021/pr101221h

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Increased plasma levels of clusterin have recently been found to be associated with severity and progression in Alzheimer's disease (AD). We have investigated clusterin levels in serum of elderly people with presymptomatic All from a population-based prospective cohort study. During 10 years follow-up, 43 participants were diagnosed with AD after on average 4.2 years (+/-2.6 years SD) after the initial blood sampling. At the time of blood sampling, these participants showed normal cognitive function. For each presymptomatic AD case, a control was matched on gender and age. Furthermore, the selected controls had to remain dementia-free and still be alive at the end of follow-up. Quantitative serum clusterin levels were measured with a newly developed multiple reaction monitoring (MRM) assay. Results of the assay showed no significant difference in clusterin levels between presymptomatic AD and controls (p-value 0.54). In conclusion, serum clusterin is not an early, presymptomatic biomarker for AD.

引用

页码：2006 / 2010

页数：5

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