The circadian system and melatonin: Lessons from rats and mice

被引：30

作者：

Korf, HW

Von Gall, C

Stehle, J

机构：

[1] Goethe Univ Frankfurt, Inst Anat 2, D-60590 Frankfurt, Germany

[2] Univ Massachusetts, Sch Med, Dept Neurobiol, Worcester, MA 01605 USA

来源：

CHRONOBIOLOGY INTERNATIONAL | 2003年 / 20卷 / 04期

关键词：

suprachiasmatic nucleus; pineal gland; pars tuberalis; melatonin; clock genes; CREB;

D O I：

10.1081/CBI-120022415

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The circadian system (CS) comprises three key components: (1) endogenous oscillators (clocks) generating a circadian rhythm; (2) input pathways entraining the circadian rhythm to the astrophysical day; and (3) output pathways distributing signals from the oscillator to the periphery. This contribution briefly reviews some general aspects of the organization of the rodent CS and pays particular attention to recent results obtained with various mouse strains, related to molecular mechanisms involved in entraining the endogenous clock and the role of the pineal hormone melatonin as a hand of the endogenous clock.

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收藏

页码：697 / 710

页数：14

相关论文

共 47 条

[1] Responses of neurones of the rat suprachiasmatic nucleus to retinal illumination under photopic and scotopic conditions [J].

Aggelopoulos, NC ;

Meissl, H .

JOURNAL OF PHYSIOLOGY-LONDON, 2000, 523 (01) :211-222

[2] Efficacy of melatonin treatment in jet lag, shift work, and blindness [J].

Arendt, J ;

Skene, DJ ;

Middleton, B ;

Lockley, SW ;

Deacon, S .

JOURNAL OF BIOLOGICAL RHYTHMS, 1997, 12 (06) :604-617

[3] Clock genes in mammalian peripheral tissues [J].

Balsalobre, A .

CELL AND TISSUE RESEARCH, 2002, 309 (01) :193-199

[4] Opsins and mammalian photoentrainment [J].

Bellingham, J ;

Foster, RG .

CELL AND TISSUE RESEARCH, 2002, 309 (01) :57-71

[5] Pituitary adenylyl cyclase-activating peptide: A pivotal modulator of glutamatergic regulation of the suprachiasmatic circadian clock [J].

Chen, D ;

Buchanan, GF ;

Ding, JM ;

Hannibal, J ;

Gillette, MU .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (23) :13468-13473

[6]

Drijfhout WJ, 1996, J NEUROCHEM, V66, P748

[7] GENETIC-CONTROL OF MELATONIN SYNTHESIS IN THE PINEAL-GLAND OF THE MOUSE [J].

EBIHARA, S ;

MARKS, T ;

HUDSON, DJ ;

MENAKER, M .

SCIENCE, 1986, 231 (4737) :491-493

[8] Control of melatonin synthesis in the mammalian pineal gland: the critical role of serotonin acetylation [J].

Ganguly, S ;

Coon, SL ;

Klein, DC .

CELL AND TISSUE RESEARCH, 2002, 309 (01) :127-137

[9] Phosphorylation of CREB Ser142 regulates light-induced phase shifts of the circadian clock [J].

Gau, D ;

Lemberger, T ;

von Gall, C ;

Kretz, O ;

Minh, NL ;

Gass, P ;

Schmid, W ;

Schibler, U ;

Korf, HW ;

Schütz, G .

NEURON, 2002, 34 (02) :245-252

[10] Signaling in the suprachiasmatic nucleus: selectively responsive and integrative [J].

Gillette, MU ;

Mitchell, JW .

CELL AND TISSUE RESEARCH, 2002, 309 (01) :99-107

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