Synthesis of new building blocks: Towards the analogs of peptide nucleic acids (PNAs)

被引：12

作者：

Dallaire, C ^{[1
]}

Arya, P ^{[1
]}

机构：

[1] Natl Res Council Canada, Steacie Inst Mol Sci, Ottawa, ON K1A 0R6, Canada

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 29期

关键词：

D O I：

10.1016/S0040-4039(98)01007-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

To obtain new analogs of peptide nucleic acids (PNAs), synthesis of the building block 14 has been achieved. Building block 14 has been derived from the coupling of the isothiocyanate derivative, 12 with 13. Isothiocyanate derivative 12 was obtained from S-aspartic acid derivative 5 in a number of steps. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：5129 / 5132

页数：4

共 20 条

[1] SEQUENCE SELECTIVE DOUBLE-STRAND DNA CLEAVAGE BY PEPTIDE NUCLEIC-ACID (PNA) TARGETING USING NUCLEASE S1
DEMIDOV, V
FRANKKAMENETSKII, MD
EGHOLM, M
BUCHARDT, O
NIELSEN, PE
[J]. NUCLEIC ACIDS RESEARCH, 1993, 21 (09) : 2103 - 2107
[2] SYNTHESIS OF THE POLYCATION THYMIDYL DNG, ITS FIDELITY IN BINDING POLYANIONIC DNA/RNA, AND THE STABILITY AND NATURE OF THE HYBRID COMPLEXES
DEMPCY, RO
BROWNE, KA
BRUICE, TC
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (22) : 6140 - 6141
[3] SYNTHESIS OF PEPTIDE NUCLEIC-ACID MONOMERS CONTAINING THE 4 NATURAL NUCLEOBASES - THYMINE, CYTOSINE, ADENINE, AND GUANINE AND THEIR OLIGOMERIZATION
DUEHOLM, KL
EGHOLM, M
BEHRENS, C
CHRISTENSEN, L
HANSEN, HF
VULPIUS, T
PETERSEN, KH
BERG, RH
NIELSEN, PE
BUCHARDT, O
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (19) : 5767 - 5773
[4] Dueholm KL, 1997, NEW J CHEM, V21, P19
[5] PNA HYBRIDIZES TO COMPLEMENTARY OLIGONUCLEOTIDES OBEYING THE WATSON-CRICK HYDROGEN-BONDING RULES
EGHOLM, M
BUCHARDT, O
CHRISTENSEN, L
BEHRENS, C
FREIER, SM
DRIVER, DA
BERG, RH
KIM, SK
NORDEN, B
NIELSEN, PE
[J]. NATURE, 1993, 365 (6446) : 566 - 568
[6] ANTISENSE AND ANTIGENE PROPERTIES OF PEPTIDE NUCLEIC-ACIDS
HANVEY, JC
PEFFER, NJ
BISI, JE
THOMSON, SA
CADILLA, R
JOSEY, JA
RICCA, DJ
HASSMAN, CF
BONHAM, MA
AU, KG
CARTER, SG
BRUCKENSTEIN, DA
BOYD, AL
NOBLE, SA
BABISS, LE
[J]. SCIENCE, 1992, 258 (5087) : 1481 - 1485
[7] HENICHART JP, 1980, SYNTHESIS-STUTTGART, P311
[8] STRUCTURE-ACTIVITY STUDIES OF THE BINDING OF MODIFIED PEPTIDE NUCLEIC-ACIDS (PNAS) TO DNA
HYRUP, B
EGHOLM, M
NIELSEN, PE
WITTUNG, P
NORDEN, B
BUCHARDT, O
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (18) : 7964 - 7970
[9] ENANTIOSELECTIVE TOTAL SYNTHESIS OF (+)-(S)-DIHYDROPERIPHYLLINE
KASEDA, T
KIKUCHI, T
KIBAYASHI, C
[J]. TETRAHEDRON LETTERS, 1989, 30 (34) : 4539 - 4542
[10] A CONVENIENT SYNTHESIS OF CHIRAL PEPTIDE NUCLEIC-ACID (PNA) MONOMERS
KOSYNKINA, L
WANG, W
LIANG, TC
[J]. TETRAHEDRON LETTERS, 1994, 35 (29) : 5173 - 5176

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