Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor

被引：116

作者：

Malet-Sanz, Laia ^{[1
,2
]}

Madrzak, Julia ^{[2
]}

Ley, Steven V. ^{[1
]}

Baxendale, Ian R. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Innovat Technol Ctr, Cambridge CB2 1EW, England

[2] Pfizer Global Res & Dev, World Wide Med Chem, Sandwich CT13 9NJ, Kent, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 23期

关键词：

ORGANIC-SYNTHESIS; CHEMISTRY; BROMOTRICHLOROMETHANE; REGIOSELECTIVITY; CYCLOADDITION; SULFONAMIDES; NITROSATION; REAGENTS; TOOL;

D O I：

10.1039/c0ob00450b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new flow procedure for the preparation of arylsulfonyl chlorides from aniline starting materials is described. The reaction conditions are mild, requiring no added acid and are amenable to continuous flow processing, in a safe, easily scalable and less labour intensive way than the corresponding batch method.

引用

页码：5324 / 5332

页数：9

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