Emerging role of SUMO in pancreatic β-cells

被引：10

作者：

Ehninger, A.

Mziaut, H.

Solimena, M.

机构：

[1] Tech Univ Dresden, Carl Gustav Carus Med Sch, D-01307 Dresden, Germany

[2] Tech Univ Dresden, Carl Gustav Carus Med Sch, Med Clin 3, D-8027 Dresden, Germany

来源：

HORMONE AND METABOLIC RESEARCH | 2007年 / 39卷 / 09期

关键词：

insulin; diabetes; ICA512; PDX-1; Maf-a; STAT; PIAS;

D O I：

10.1055/s-2007-985372

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Post-translational attachment of small ubiquitin-like modifier (SUMO), defined as SUMOylation, can affect the localization, interactions, stability and/or activity of substrate proteins, and thus can participate in a large variety of cellular processes. Most SUMO substrates are involved in transcriptional regulation. Hence, SUMOylation can either activate or, more commonly, repress gene transcription. The modulation of gene expression by SUMO through diverse mechanisms and specifically the recent findings concerning SUMOylation in pancreatic beta-cells are reviewed.

引用

收藏

页码：658 / 664

页数：7

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