Usefulness and safety of bepridil in converting persistent atrial fibrillation to sinus rhythm

被引：64

作者：

Fujiki, A ^{[1
]}

Tsuneda, T ^{[1
]}

Sugao, M ^{[1
]}

Mizumaki, K ^{[1
]}

Inoue, H ^{[1
]}

机构：

[1] Toyama Med & Pharmaceut Univ, Dept Internal Med 2, Sugitani, Toyama 9300194, Japan

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2003年 / 92卷 / 04期

关键词：

D O I：

10.1016/S0002-9149(03)00672-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this study was to investigate the efficacy and safety of bepridil (a multichannel blocker including several potassium channels) for conversion of long-lasting atrial fibrillation (AF). Bepridil restored sinus rhythm alone or in combination with aprindine in 69% of 32 patients with persistent AF lasting greater than or equal to3 months. The time to conversion after starting bepridil was 30 +/- 12 days. An increase in fibrillation cycle length with bepridil was greater in responders (31 +/- 10%), but an increase in QTc did not differ between responders and nonresponders. Bepridil is effective and safe for terminating long-lasting persistent AF. (C)2003 by Excerpta Medica, Inc.

引用

页码：472 / 475

页数：4

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