The antihyperglycaemic activity of berberine arises from a decrease of glucose absorption

被引：65

作者：

Pan, GY ^{[1
]}

Huang, ZJ

Wang, GJ

Fawcett, JP

Liu, XD

Zhao, XC

Sun, JG

Xie, YY

机构：

[1] China Pharmaceut Univ, Ctr Pharmacokinet 210, Nanjing 210009, Peoples R China

[2] Univ Otago, Sch Pharm, Dunedin, New Zealand

来源：

PLANTA MEDICA | 2003年 / 69卷 / 07期

关键词：

berberine; Caco-2; cells; alpha-glucosidase inhibitor; diabetes;

D O I：

暂无

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The mechanism of action of berberine as an antihyperglycaemic agent was investigated in the Caco-2 cell line. Berberine was found to effectively inhibit the activity of disaccharidases in Caco-2 cells. It also decreased sucrase activity after preincubation with Caco-2 cells for 72 hours. However gluconeogenesis and glucose consumption of Caco-2 cells were not influenced. 2-Deoxyglucose transporting through Caco-2 cell monolayers was decreased by berberine but the effect. was not statistically significant. These results suggest that the antihyperglycaemic activity of berberine is at least partly due to its ability to inhibit a-glucosidase and decrease glucose transport through the intestinal epithelium.

引用

页码：632 / 636

页数：5

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