Gold nanorods mediate tumor cell death by compromising membrane integrity

被引：509

作者：

Tong, Ling

Zhao, Yan

Huff, Terry B.

Hansen, Matthew N.

Wei, Alexander ^{[1
]}

Cheng, Ji-Xin

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

[2] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA

来源：

ADVANCED MATERIALS | 2007年 / 19卷 / 20期

关键词：

D O I：

10.1002/adma.200701974

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Folate-conjugated gold nanorods targeted to tumor cell surfaces produced severe membrane damage upon near-infrared irradiation. Photoinduced injury to the plasma membrane resulted in a rapid increase in intracellular calcium (shown in green) with subsequent disruption of the actin network, featured prominently by the formation of membrane blebs.

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收藏

页码：3136 / +

页数：7

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