Convergent synthesis and antibacterial activity of pyrazole and pyrazoline derivatives of diazepam

被引：70

作者：

Berghot, MA ^{[1
]}

Moawad, EB ^{[1
]}

机构：

[1] Mansoura Univ, Fac Sci, Dept Chem, Mansoura 35516, Egypt

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2003年 / 20卷 / 02期

关键词：

diazepam; pyrazoles; pyrazolines;

D O I：

10.1016/S0928-0987(03)00162-3

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Polysubstituted pyrazoles (5)(a-l), pyrazolines (7)(a-c), (8)(a-c) and pyrazolotriazine (10) derivatives of diazepam were synthesized. The structures of hitherto unknown compounds were established by analytical and spectral methods. Some of these compounds were screened to test their antibacterial activity against gram-positive (B. subtilis) and gram-negative (P. aeruginosa). All compounds showed potent activity against these bacteria. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：173 / 179

页数：7

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