Stereoselective synthesis of β-branched Baylis-Hillman adducts via organozinc species

被引：25

作者：

Xue, S ^{[1
]}

He, L ^{[1
]}

Han, KZ ^{[1
]}

Liu, YK ^{[1
]}

Guo, QX ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China

来源：

SYNLETT | 2005年 / 08期

关键词：

Baylis-Hillman adducts; organozinc species; acetylenic ketones; aldehydes;

D O I：

10.1055/s-2005-868483

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient one-pot, three-component coup ling reaction for the synthesis of unusual P-branched Baylis-Hillman adducts has been developed. Organozine species CF3CO2ZnEt added to alpha,beta-acetylenic ketones in a 1,4-fashion to yield allenolates, which reacted with aldehydes providing highly functionalized trisubstituted olefins in good to excellent yields with stereoselectivity.

引用

页码：1247 / 1250

页数：4

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