Resistance to viral infection of super p53 mice

被引：65

作者：

Munoz-Fontela, C

Garcia, MA

Garcia-Cao, I

Collado, M

Arroyo, J

Esteban, M

Serrano, M

Rivas, C

机构：

[1] Univ Complutense Madrid, Fac Farm, Dept Microbiol 2, E-28040 Madrid, Spain

[2] CSIC, Ctr Nacl Biotecnol, Madrid, Spain

[3] CNIO, Madrid, Spain

来源：

ONCOGENE | 2005年 / 24卷 / 18期

关键词：

p53; vesicular stomatitis virus; vaccinia virus; tumor suppressor; antiviral activity; `super p53' mice;

D O I：

10.1038/sj.onc.1208477

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Induction of expression of the tumor suppressor p53 after interferon treatment has been recently demonstrated (Takaoka et al., 2003), suggesting an antiviral activity of the protein. In addition, a direct correlation between p53 levels and tumor resistance has been addressed by generating mice with an extra copy of p53 ('super p53' mice) (Garcia-Cao et al., 2002). Here, we show that vesicular stomatitis virus replication in mouse embryo fibroblasts derived from 'super p53' mice is impaired as a result of apoptosis induction via p53 activation. These findings unequivocally demonstrate an antiviral activity of p53, a process that may contribute to inhibit the spread of the virus in vivo.

引用

页码：3059 / 3062

页数：4

共 28 条

[1] Oncolytic activity of vesicular stomatitis virus is effective against tumors exhibiting aberrant p53, Ras, or Myc function and involves the induction of apoptosis [J].