Combined measurement of PEDF, haptoglobin and tau in cerebrospinal fluid improves the diagnostic discrimination between alzheimer's disease and other dementias

被引：17

作者：

Abraham, Jean-Daniel ^{[1
]}

Calvayrac-Pawlowski, Sophie ^{[1
]}

Cobo, Sandra ^{[1
]}

Salvetat, Nicolas ^{[1
]}

Vicat, Guillaume ^{[1
]}

Molina, Laurence ^{[1
]}

Touchon, Jacques ^{[2
]}

Michel, Bernard-Francois ^{[3
,4
,5
]}

Molina, Franck ^{[1
]}

Verdier, Jean-Michel ^{[3
,4
,5
]}

Fareh, Jeannette ^{[1
]}

Mourton-Gilles, Chantal ^{[1
]}

机构：

[1] SysDiag CNRS, Bio Rad UMR3145, Montpellier, France

[2] Gui Chauliac Hosp, Neurol Serv, Montpellier, France

[3] Univ Montpellier 2, F-34095 Montpellier, France

[4] INSERM, U710, F-34095 Montpellier, France

[5] EPHE, F-75007 Paris, France

来源：

BIOMARKERS | 2011年 / 16卷 / 02期

关键词：

Neurological disease; Biomarker; ROC; Cognitive Test; EPITHELIUM-DERIVED FACTOR; OPERATING CHARACTERISTIC CURVES; MILD COGNITIVE IMPAIRMENT; NEUROTROPHIC FACTOR; PHOSPHORYLATED-TAU; DIFFERENTIAL-DIAGNOSIS; OXIDATIVE STRESS; CELL-LINES; CSF; MARKERS;

D O I：

10.3109/1354750X.2010.536995

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Using proteomic approach in cerebrospinal fluid (CSF) we identified pigment epithelium-derived factor (PEDF) and Haptoglobin (Hp) as putative markers that could discriminate between AD and other dementias. ELISA assays were developed to measure the levels of PEDF and Hp in CSF from patients with AD (AD, n == 27), non-AD (NAD, n == 30) and in non-demented patients (ND, n == 27). The combined assessment of PEDF, Hp and Tau levels, using Iterative Marginal Optimization, improved the differential diagnosis of AD, especially in patients with moderate to severe dementia (p < 0.002). This pilot study highlights the probable different contribution of oxidative mechanisms in dementia.</.

引用

页码：161 / 171

页数：11

共 64 条

[1]

Abdi F, 2006, J ALZHEIMERS DIS, V9, P293

[2] Pigment epithelium-derived factor inhibits oxidative stress-induced apoptosis and dysfunction of cultured retinal pericytes [J].

Amano, S ;

Yamagishi, S ;

Inagaki, Y ;

Nakamura, K ;

Takeuchi, M ;

Inoue, H ;

Imaizumi, T .

MICROVASCULAR RESEARCH, 2005, 69 (1-2) :45-55

[3] Evaluation of CSF-tau and CSF-Aβ42 as diagnostic markers for Alzheimer disease in clinical practice [J].

Andreasen, N ;

Minthon, L ;

Davidsson, P ;

Vanmechelen, E ;

Vanderstichele, H ;

Winblad, B ;

Blennow, K .

ARCHIVES OF NEUROLOGY, 2001, 58 (03) :373-379

[4] Amyloid-β peptide binds with heme to form a peroxidase:: Relationship to the cytopathologies of Alzheimer's disease [J].

Atamna, H ;

Boyle, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (09) :3381-3386

[5] CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].

BENJAMINI, Y ;

HOCHBERG, Y .

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) :289-300

[6] Pigment epithelium-derived factor (PEDF) protects motor neurons from chronic glutamate-mediated neurodegeneration [J].

Bilak, MM ;

Corse, AM ;

Bilak, SR ;

Lehar, M ;

Tombran-Tink, J ;

Kuncl, RW .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1999, 58 (07) :719-728

[7] Differential post-translational modifications of transthyretin in Alzheimer's disease: A study of the cerebral spinal fluid [J].

Biroccio, A ;

del Boccio, P ;

Panella, M ;

Bernardini, S ;

Di Ilio, C ;

Gambi, D ;

Stanzione, P ;

Sacchetta, P ;

Bernardi, G ;

Martorana, A ;

Federici, G ;

Stefani, A ;

Urbani, A .

PROTEOMICS, 2006, 6 (07) :2305-2313

[8] CSF markers for incipient Alzheimer's disease [J].

Blennow, K ;

Hampel, H .

LANCET NEUROLOGY, 2003, 2 (10) :605-613

[9] Role of complement in neurodegeneration and neuroinflammation [J].

Bonifati, Domenico Marco ;

Kishore, Uday .

MOLECULAR IMMUNOLOGY, 2007, 44 (05) :999-1010

[10] Phosphorylated tau predicts rate of cognitive decline in MCI subjects: A comparative CSF study [J].

Buerger, K ;

Ewers, M ;

Andreasen, N ;

Zinkowski, R ;

Ishiguro, K ;

Vanmechelen, E ;

Teipel, SJ ;

Graz, C ;

Blennow, K ;

Hampel, H .

NEUROLOGY, 2005, 65 (09) :1502-1503

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