Isocratic high-performance liquid chromatographic method with ultraviolet detection for simultaneous determination of levels of voriconazole and Itraconazole and its hydroxy metabolite in human serum

被引：49

作者：

Khoschsorur, G ^{[1
]}

Fruehwirth, F ^{[1
]}

Zelzer, S ^{[1
]}

机构：

[1] Med Univ Graz, Inst Med & Chem Lab Diagnost, LBI, A-8036 Graz, Austria

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 08期

关键词：

D O I：

10.1128/AAC.49.8.3569-3571.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A simple, specific method is presented for simultaneous determination of voriconazole and itraconazole and its metabolite, hydroxyitraconazole, in human serum using one-step liquid-liquid extraction and high-performance liquid chromatography. Linearity tests ranged from 0.1 to 8.0 mu g/ml; the minimum detectable concentration was 0.03 mu g/ml.

引用

页码：3569 / 3571

页数：3

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