Kainic acid-induced neuronal loss and glial changes in the hippocampal CA3 of p53-deficient mouse

被引：10

作者：

Kitamura, Y

Ota, T

Matsuoka, Y

Okazaki, M

Kakimura, J

Tooyama, I

Kimura, H

Shimohama, S

Gebicke-Haerter, PJ

Nomura, Y

Taniguchi, T ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Dept Neurobiol, Kyoto 6078412, Japan

[2] Shiga Univ Med Sci, Inst Mol Neurobiol, Div Neurochem, Otsu, Shiga 5202192, Japan

[3] Shiga Univ Med Sci, Inst Mol Neurobiol, Div Neuroanat, Otsu, Shiga 5202192, Japan

[4] Kyoto Univ, Fac Med, Dept Neurol, Kyoto 6068507, Japan

[5] Univ Freiburg, Dept Psychiat & Psychotherapy, D-79104 Freiburg, Germany

[6] Hokkaido Univ, Fac Pharmaceut Sci, Dept Pharmacol, Sapporo, Hokkaido 0600812, Japan

来源：

NEUROSCIENCE LETTERS | 1998年 / 255卷 / 01期

关键词：

p53-deficient mouse; kainic acid; phosphorylated c-Jun; neuronal loss; microglia; astrocytes; hippocampal CA3;

D O I：

10.1016/S0304-3940(98)00714-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

We examined kainic acid (KA)-induced neuronal death and changes in glial cells in p53-deficient (p53(-/-)) and wild-type (p53(+/+)) mice which were CBA and C57BL/6 background. The p53(-/-) mouse exhibited a KA-induced loss of CA3 pyramidal neurons similar to that in wild-type mouse. Before neuronal death, c-Jun protein was expressed, phosphorylated and translocated into several nuclei of CA3 pyramidal neurons. In p53(-/-) mouse, microglial activation was slightly faster and more continuous after 1-7 days than that in p53(+/+) mouse. On the other hand, p53(-/-) astrocytes were relatively resistant to KA cytotoxicity, and marked astrocytosis also occurred after 7 days. These observations suggest that p53-null mutation may influence the activation and proliferation of glial cells rather than neuronal death. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：57 / 60

页数：4

共 15 条

[1]

THE KINETICS AND MORPHOLOGICAL-CHARACTERISTICS OF THE MACROPHAGE MICROGLIAL RESPONSE TO KAINIC ACID-INDUCED NEURONAL DEGENERATION [J].