Neural network modeling of central auditory dysfunction in Alzheimer's disease

被引:10
作者
Krishnamurti, Sridhar [1 ]
Drake, Lyle [1 ]
King, Justin [1 ]
机构
[1] Auburn Univ, Haley Ctr 1199, Auburn, AL 36849 USA
关键词
Neural networks; Central auditory dysfunction; NEUROFIBRILLARY TANGLES; NEURITIC PLAQUES; INFORMATION; DEMENTIA; SPEECH; CORTEX; BRAIN;
D O I
10.1016/j.neunet.2011.02.010
中图分类号
TP18 [人工智能理论];
学科分类号
140502 [人工智能];
摘要
Background: Many reports have described that individuals with Alzheimer's disease show neural breakdown in the brainstem nuclei, hippocampus and auditory cortex in the temporal lobe of the brain. However, it is still unclear whether auditory skills mediated by these areas differ across individuals with and without Alzheimer's disease and how these auditory skills are further confounded by reduction in cognitive function in individuals with AD. Aim: The aim of this study is to discover the hidden and nonlinear associations among higher-order auditory and cognitive processes in individuals with and without Alzheimer's disease through artificial neural network analysis. Methods: The analyses were based on auditory test data obtained from nine clinically confirmed Alzheimer's disease cases and nine age-matched controls. Hearing threshold sensitivity was equivalent across groups, indicating similar peripheral auditory function. Auditory function was evaluated by standardized tests of auditory closure, auditory attention, and auditory figure ground in listeners with and without Alzheimer's disease. The inputs used for analyses were cognitive status and auditory function. The dependent variables were RAU scores computed from scores of auditory tests. Results: Artificial neural networks showed a complex relationship between the input variables (cognitive status and auditory function) that cannot be predicted simply on the basis of cognition differences between individuals with and without Alzheimer's disease. Conclusion: The results of this study suggest that central auditory function declines with age, regardless of changes in cognitive function. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码:646 / 651
页数:6
相关论文
共 38 条
[1]
Adams RD., 1989, PRINCIPLES NEUROLOGY, V4th
[2]
The Topographical and Neuroanatomical Distribution of Neurofibrillary Tangles and Neuritic Plaques in the Cerebral Cortex of Patients with Alzheimer's Disease [J].
Arnold, Steven E. ;
Hyman, Bradley T. ;
Flory, Jill ;
Damasio, Antonio R. ;
Van Hoesen, Gary W. .
CEREBRAL CORTEX, 1991, 1 (01) :103-116
[3]
Baran Jane A, 2004, J Am Acad Audiol, V15, P106, DOI 10.3766/jaaa.15.2.2
[4]
Bellis T., 2003, T DELMAR LEARNING AS
[5]
Context-Dependent Encoding in the Human Auditory Brainstem Relates to Hearing Speech in Noise: Implications for Developmental Dyslexia [J].
Chandrasekaran, Bharath ;
Hornickel, Jane ;
Skoe, Erika ;
Nicol, Trent ;
Kraus, Nina .
NEURON, 2009, 64 (03) :311-319
[6]
The scalp-recorded brainstem response to speech: Neural origins and plasticity [J].
Chandrasekaran, Bharath ;
Kraus, Nina .
PSYCHOPHYSIOLOGY, 2010, 47 (02) :236-246
[7]
THE PROGNOSIS IN ALZHEIMERS-DISEASE - HOW FAR RATHER THAN HOW FAST BEST PREDICTS THE COURSE [J].
DRACHMAN, DA ;
ODONNELL, BF ;
LEW, RA ;
SWEARER, JM .
ARCHIVES OF NEUROLOGY, 1990, 47 (08) :851-856
[8]
Elgh E., 2005, SOC BIOL PSYCHIAT, V59, P155
[9]
THE CORTEX OF THE PRIMARY AUDITORY AREA IN ALZHEIMERS-DISEASE [J].
ESIRI, MM ;
PEARSON, RCA ;
POWELL, TPS .
BRAIN RESEARCH, 1986, 366 (1-2) :385-387
[10]
Central auditory dysfunction may precede the onset of clinical dementia in people with probable Alzheimer's disease [J].
Gates, GA ;
Beiser, A ;
Rees, TS ;
D'Agostino, RB ;
Wolf, PA .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2002, 50 (03) :482-488