The effects of local insulin delivery on diabetic fracture healing

被引：146

作者：

Gandhi, A ^{[1
]}

Beam, HA ^{[1
]}

O'Connor, JP ^{[1
]}

Parsons, JR ^{[1
]}

Lin, SS ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Dept Orthopaed, New Jersey Med Sch, Newark, NJ 07103 USA

来源：

BONE | 2005年 / 37卷 / 04期

关键词：

diabetes mellitus; fracture; BB Wistar rat; insulin; drug delivery;

D O I：

10.1016/j.bone.2005.04.039

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Several studies have documented that diabetes impairs bone healing clinically and experimentally. Systemic insulin treatment has been shown to ameliorate impaired diabetic bone healing. However, these studies failed to distinguish between a direct and a systemic effect of insulin upon bone healing. A novel intramedullary insulin delivery system was used in the diabetic 1313 Wistar femur fracture model to investigate the potential direct effects of insulin on bone healing. Insulin delivery at the fracture site normalized the early (cellular proliferation and chondrogenesis) and late (mineralized tissue, cartilage content and mechanical strength) parameters of diabetic fracture healing without affecting the systemic parameters of blood glucose. These results suggest a critical role for insulin in directly mediating fracture healing and that decreased systemic insulin levels in the diabetic state lead to reduced localized insulin levels at fracture site with concomitant increases in diabetic fracture healing time. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：482 / 490

页数：9

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