Antibody responses and cross protection against lethal influenza A viruses differ between the sexes in C57BL/6 mice

被引：79

作者：

Lorenzo, Maria E. ^{[1
,3
]}

Hodgson, Andrea ^{[1
]}

Robinson, Dionne P. ^{[1
]}

Kaplan, Jenifer B. ^{[1
]}

Pekosz, Andrew ^{[1
]}

Klein, Sabra L. ^{[1
,2
]}

机构：

[1] Johns Hopkins Bloomberg Sch Publ Hlth, W Harry Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA

[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biochem & Mol Biol, Baltimore, MD 21205 USA

[3] Johns Hopkins Sch Med, Dept Mol & Comparat Pathobiol, Baltimore, MD USA

来源：

VACCINE | 2011年 / 29卷 / 49期

关键词：

Humoral immunity; Influenza vaccine; Sex difference; T-LYMPHOCYTE RESPONSES; HEALTH-CARE WORKERS; HETEROSUBTYPIC IMMUNITY; AVIAN INFLUENZA; CELL IMMUNITY; A/H3N2; VIRUS; INFECTION; VACCINATION; H5N1; CHALLENGE;

D O I：

10.1016/j.vaccine.2011.09.110

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A mouse model was used to determine if protective immunity to influenza A virus infection differs between the sexes. The median lethal dose of H1N1 or H3N2 was lower for naive females than males. After a sublethal, primary infection with H1N1 or H3N2, females and males showed a similar transient morbidity, but females generated more neutralizing and total anti-influenza A virus antibodies. Immunized males and females showed similar protection against secondary challenge with a homologous virus, but males experienced greater morbidity and had higher lung viral titers after infection with a lethal dose of heterologous virus. Females develop stronger humoral immune responses and greater cross protection against heterosubtypic virus challenge. (C) 2011 Elsevier Ltd. All rights reserved.

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页码：9246 / 9255

页数：10

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