Effect of non-alcoholic compounds of alcoholic drinks on the pancreas

被引:13
作者
Feick, Peter [1 ]
Gerloff, Andreas [1 ]
Singer, Manfred V. [1 ]
机构
[1] Univ Heidelberg Hosp, Dept Med 2, DE-68135 Mannheim, Germany
关键词
alcohol; alcoholic beverages; non-alcoholic compounds; pancreatitis;
D O I
10.1159/000104237
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Over the past 30 years the role of alcohol ( ethanol) in the development of acute and chronic pancreatitis has been intensively investigated. However, ethanol is generally consumed in form of alcoholic beverages which contain numerous non-alcoholic compounds. At least on gastric acid secretion it has been convincingly demonstrated that alcohol and alcoholic beverages have markedly different effects. In the present article, we provide an overview about the effect of different non-alcoholic constituents of alcoholic beverages on the pancreas and their possible interaction with molecular mechanisms leading to 'alcoholic' pancreatitis. The present data indicate that pancreatic enzyme secretion in humans is stimulated by non-alcoholic constituents of beer which are generated by alcoholic fermentation of glucose. In addition, it has been shown that natural phenolic compounds ( e. g. quercetin, resveratrol) of alcoholic beverages exert different effects on the pancreas in vitro, such as inhibition of pancreatic enzyme output, of pancreatic stellate cell activation and of pancreatic cancer growth as well as protective effects against oxidative stress and on experimental induced acute pancreatitis in rats. However, it should be pointed out that alcoholic beverages contain much more non-alcoholic ingredients. Since the effects of these are still unknown, caution is required in attempting to define alcoholic etiology of pancreatitis without considering the effect of non-alcoholic compounds of alcoholic beverages. Copyright (c) 2007 S. Karger AG, Basel and IAP
引用
收藏
页码:124 / 130
页数:7
相关论文
共 21 条
[1]   Heat shock protein 70 prevents secretagogue-induced cell injury in the pancreas by preventing intracellular trypsinogen activation [J].
Bhagat, L ;
Singh, VP ;
Hietaranta, AJ ;
Agrawal, S ;
Steer, ML ;
Saluja, AK .
JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (01) :81-89
[2]   Effect of beer, yeast-fermented glucose, and ethanol on pancreatic enzyme secretion in healthy human subjects [J].
Chari, ST ;
Harder, H ;
Teyssen, S ;
Knodel, C ;
Riepl, RL ;
Singer, MV .
DIGESTIVE DISEASES AND SCIENCES, 1996, 41 (06) :1216-1224
[3]   EFFECT OF ALCOHOL AND ALCOHOLIC BEVERAGES ON MEAL-STIMULATED PANCREATIC-SECRETION IN HUMANS [J].
HAJNAL, F ;
FLORES, MC ;
RADLEY, S ;
VALENZUELA, JE .
GASTROENTEROLOGY, 1990, 98 (01) :191-196
[4]   EFFECT OF ALCOHOL AND ALCOHOLIC BEVERAGES ON NONSTIMULATED PANCREATIC-SECRETION IN HUMANS [J].
HAJNAL, F ;
FLORES, MC ;
VALENZUELA, JE .
PANCREAS, 1989, 4 (04) :486-491
[5]  
Lawinski M, 2005, PANCREAS, V31, P43, DOI 10.1097/01.mpa.0000163021.40607.20
[6]   SELECTIVITY OF QUERCETIN INHIBITION ON STIMULATED AMYLASE RELEASE IN RAT PANCREATIC ACINI [J].
LEE, PC ;
SHIMIZU, K ;
ROSSI, TM ;
CUMELLA, JC .
PANCREAS, 1988, 3 (03) :317-323
[7]   Effect of resveratrol on pancreatic oxygen free radicals in rats with severe acute pancreatitis [J].
Li, Zhen-Dong ;
Ma, Qing-Yong ;
Wang, Chang-An .
WORLD JOURNAL OF GASTROENTEROLOGY, 2006, 12 (01) :137-140
[8]   Effect of resveratrol on peritoneal macrophages in rats with severe acute pancreatitis [J].
Ma, ZH ;
Ma, QY ;
Wang, LC ;
Sha, HC ;
Wu, SL ;
Zhang, M .
INFLAMMATION RESEARCH, 2005, 54 (12) :522-527
[9]   Ellagic acid blocks activation of pancreatic stellate cells [J].
Masamune, A ;
Satoh, M ;
Kikuta, K ;
Suzuki, N ;
Satoh, K ;
Shimosegawa, T .
BIOCHEMICAL PHARMACOLOGY, 2005, 70 (06) :869-878
[10]   Effect of resveratrol on activation of nuclear factor kappa-B and inflammatory factors in rat model of acute pancreatitis [J].
Meng, Yong ;
Ma, Qing-Yong ;
Kou, Xiao-Ping ;
Xu, Jun .
WORLD JOURNAL OF GASTROENTEROLOGY, 2005, 11 (04) :525-528