Neurotoxicity of MDMA (ecstasy): beyond metabolism

被引:13
作者
Sprague, JE [1 ]
Nichols, DE
机构
[1] Virginia Polytech Inst & State Univ, Virginia Coll Osteopath Med, Blacksburg, VA 24060 USA
[2] Virginia Polytech Inst & State Univ, Dept Biomed Sci & Pathobiol, Blacksburg, VA 24060 USA
[3] Purdue Univ, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA
关键词
D O I
10.1016/j.tips.2004.12.001
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:59 / 60
页数:2
相关论文
共 19 条
[1]   Disposition of methylenedioxymethamphetamine and three metabolites in the brains of different rat strains and their possible roles in acute serotonin depletion [J].
Chu, T ;
Kumagai, Y ;
DiStefano, EW ;
Cho, AK .
BIOCHEMICAL PHARMACOLOGY, 1996, 51 (06) :789-796
[2]   In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ('ecstasy') and p-chloroamphetamine but not the degeneration following fenfluramine [J].
Colado, MI ;
OShea, E ;
Granados, R ;
Murray, TK ;
Green, AR .
BRITISH JOURNAL OF PHARMACOLOGY, 1997, 121 (05) :889-900
[3]   THE HYPERTHERMIC AND NEUROTOXIC EFFECTS OF ECSTASY (MDMA) AND 3,4-METHYLENEDIOXYAMPHETAMINE (MDA) IN THE DARK-AGOUTI (DA) RAT, A MODEL OF THE CYP2D6 POOR METABOLIZER PHENOTYPE [J].
COLADO, MI ;
WILLIAMS, JL ;
GREEN, AR .
BRITISH JOURNAL OF PHARMACOLOGY, 1995, 115 (07) :1281-1289
[4]   The relationship between hyperthermia and glycogenolysis in 3,4-methylenedioxymethamphetamine-induced serotonin depletion in rats [J].
Darvesh, AS ;
Gudelsky, GA .
NEUROTOXICOLOGY AND TERATOLOGY, 2004, 26 (04) :571-577
[5]   Neurotoxicity of MDMA (ecstasy):: the limitations of scaling from animals to humans [J].
de la Torre, R ;
Farré, M .
TRENDS IN PHARMACOLOGICAL SCIENCES, 2004, 25 (10) :505-508
[6]   3,4-Methylenedioxymethamphetamine induces monoamine release, but not toxicity, when administered centrally at a concentration occurring following a peripherally injected nenrotoxic dose [J].
Esteban, B ;
O'Shea, E ;
Camarero, J ;
Sanchez, V ;
Green, AR ;
Colado, MI .
PSYCHOPHARMACOLOGY, 2001, 154 (03) :251-260
[7]   An antisense oligonucleotide targeted at MAO-B attenuates rat striatal serotonergic neurotoxicity induced by MDMA [J].
Falk, EM ;
Cook, VJ ;
Nichols, DE ;
Sprague, JE .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2002, 72 (03) :617-622
[8]   The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") [J].
Green, AR ;
Mechan, AO ;
Elliott, JM ;
O'Shea, E ;
Colado, MI .
PHARMACOLOGICAL REVIEWS, 2003, 55 (03) :463-508
[9]   REDUCTION IN BRAIN-SEROTONIN MARKERS BY ALPHA-ETHYLTRYPTAMINE (MONASE) [J].
HUANG, XM ;
JOHNSON, MP ;
NICHOLS, DE .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 200 (01) :187-190
[10]   Thioether metabolites of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine inhibit human serotonin transporter (hSERT) function and simultaneously stimulate dopamine uptake into hSERT-expressing SK-N-MC cells [J].
Jones, DC ;
Lau, SS ;
Monks, TJ .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2004, 311 (01) :298-306