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Lithium perchlorate/diethylether catalyzed aminophosphonation of aldehydes

被引：78
作者：
Heydari, A
Karimian, A
Ipaktschi, J
机构：
[1] Tarbiat Modares Univ, Dept Chem, Tehran, Iran
[2] Justus Liebig Univ, Inst Organ Chem, D-35392 Giessen, Germany
来源：
TETRAHEDRON LETTERS | 1998年 / 39卷 / 37期
关键词：
D O I：
10.1016/S0040-4039(98)01411-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and general one-pot method was developed to give a-amino phosphonates from aldehydes + amines + dimethyl phosphite in LPDE. Optically active a-amino phosphonates were synthesized using (R)-(+), (S)-(-) alpha-methylbenzylamine, (R)-(-), (S)-(+) 2-phenylglycinol. (R)-(+) alpha-methylbenzylamine affords predominantly(S)-alpha-amino phosphonates and (R)-(-) 2-phenylglycinol leads predominantly to (R)-alpha-amino phosphonates. (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码：6729 / 6732
页数：4
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