Cancer to bone: a fatal attraction

被引：963

作者：

Weilbaecher, Katherine N. ^{[1
]}

Guise, Theresa A. ^{[2
]}

McCauley, Laurie K. ^{[3
,4
]}

机构：

[1] Washington Univ, Sch Med, Dept Med, Div Mol Oncol, St Louis, MO 63110 USA

[2] Indiana Univ Sch Med, Dept Med, Div Endocrinol, Indianapolis, IN 46202 USA

[3] Univ Michigan, Sch Dent, Dept Periodont & Oral Med, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

来源：

NATURE REVIEWS CANCER | 2011年 / 11卷 / 06期

基金：

美国国家卫生研究院;

关键词：

CALCIUM-SENSING RECEPTOR; HUMAN BREAST-CANCER; HUMAN PROSTATE-CANCER; GROWTH-FACTOR-BETA; HORMONE-RELATED PROTEIN; MESENCHYMAL STEM-CELLS; NF-KAPPA-B; TRANSCRIPTION FACTOR RUNX2; TUMOR-GROWTH; EXTRACELLULAR CALCIUM;

D O I：

10.1038/nrc3055

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

When cancer metastasizes to bone, considerable pain and deregulated bone remodelling occurs, greatly diminishing the possibility of cure. Metastasizing tumour cells mobilize and sculpt the bone microenvironment to enhance tumour growth and to promote bone invasion. Understanding the crucial components of the bone microenvironment that influence tumour localization, along with the tumour-derived factors that modulate cellular and protein matrix components of bone to favour tumour expansion and invasion, is central to the pathophysiology of bone metastases. Basic findings of tumour-bone interactions have uncovered numerous therapeutic opportunities that focus on the bone microenvironment to prevent and treat bone metastases.

引用

页码：411 / 425

页数：15

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