Doxycycline is anti-inflammatory and inhibits staphylococcal exotoxin-induced cytokines and chemokines

被引：126

作者：

Krakauer, T ^{[1
]}

Buckley, M ^{[1
]}

机构：

[1] USA, Dept Immunol & Mol Biol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 11期

关键词：

D O I：

10.1128/AAC.47.11.3630-3633.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

Proinflammatory cytokines mediate the toxic effect of superantigenic staphylococcal exotoxins (SE). Doxycycline inhibited SE-stimulated T-cell proliferation and production of cytokines and chemokines by human peripheral blood mononuclear cells. These results suggest that the antibiotic doxycycline has anti-inflammatory effects and is therapeutically useful for mitigating the pathogenic effects of SE.

引用

页码：3630 / 3633

页数：4

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