The contribution of underdosing to antimalarial treatment failure has been underappreciated. Most recommended dosage regimens are based on studies in non-pregnant adult patients. Young children and pregnant women, who bear the heaviest malaria burden, have the highest treatment failure rates. This has been attributed previously to lower immunity, although blood concentrations of many antimalarial drugs are significantly lower in pregnant women and young children than in non-pregnant adults. Nevertheless, there have been no studies of higher dosages. Sub-therapeutic concentrations will certainly contribute to poorer responses to treatment and will fuel the emergence and spread of antimalarial drug resistance. There is an urgent need for studies to optimise antimalarial dosage regimens in infants, young children and pregnant women, both to improve cure rates and to prolong the useful therapeutic lives of antimalarial drugs.
机构:
Shoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Mahidol Univ, Fac Trop Med, Bangkok 10700, Thailand
Churchill Hosp, Ctr Clin Vaccinol & Trop Med, Oxford OX3 7LJ, EnglandShoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Ashley, Elizabeth A.
;
Stepniewska, Kasia
论文数: 0引用数: 0
h-index: 0
机构:
Mahidol Univ, Fac Trop Med, Bangkok 10700, Thailand
Churchill Hosp, Ctr Clin Vaccinol & Trop Med, Oxford OX3 7LJ, EnglandShoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Stepniewska, Kasia
;
Lindegardh, Niklas
论文数: 0引用数: 0
h-index: 0
机构:
Mahidol Univ, Fac Trop Med, Bangkok 10700, Thailand
Churchill Hosp, Ctr Clin Vaccinol & Trop Med, Oxford OX3 7LJ, EnglandShoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Lindegardh, Niklas
;
McGready, Rose
论文数: 0引用数: 0
h-index: 0
机构:
Shoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Mahidol Univ, Fac Trop Med, Bangkok 10700, Thailand
Churchill Hosp, Ctr Clin Vaccinol & Trop Med, Oxford OX3 7LJ, EnglandShoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
McGready, Rose
;
Annerberg, Anna
论文数: 0引用数: 0
h-index: 0
机构:
Mahidol Univ, Fac Trop Med, Bangkok 10700, ThailandShoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Annerberg, Anna
;
Hutagalung, Robert
论文数: 0引用数: 0
h-index: 0
机构:
Shoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Mahidol Univ, Fac Trop Med, Bangkok 10700, ThailandShoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Hutagalung, Robert
;
Singtoroj, Thida
论文数: 0引用数: 0
h-index: 0
机构:
Mahidol Univ, Fac Trop Med, Bangkok 10700, ThailandShoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Singtoroj, Thida
;
Hla, Gilvary
论文数: 0引用数: 0
h-index: 0
机构:
Shoklo Res Unit, POB 46, Mae Sot 63110, Tak, ThailandShoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Hla, Gilvary
;
Brockman, Al
论文数: 0引用数: 0
h-index: 0
机构:
Shoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Mahidol Univ, Fac Trop Med, Bangkok 10700, Thailand
Churchill Hosp, Ctr Clin Vaccinol & Trop Med, Oxford OX3 7LJ, England
Charles Darwin Univ, Menzies Sch Hlth Res, Darwin, NT, AustraliaShoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Brockman, Al
;
Proux, Stephane
论文数: 0引用数: 0
h-index: 0
机构:
Shoklo Res Unit, POB 46, Mae Sot 63110, Tak, ThailandShoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Proux, Stephane
;
Wilahphaingern, Jahser
论文数: 0引用数: 0
h-index: 0
机构:
Shoklo Res Unit, POB 46, Mae Sot 63110, Tak, ThailandShoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Wilahphaingern, Jahser
;
论文数: 引用数:
h-index:
机构:
Singhasivanon, Pratap
;
White, Nicholas J.
论文数: 0引用数: 0
h-index: 0
机构:
Mahidol Univ, Fac Trop Med, Bangkok 10700, Thailand
Churchill Hosp, Ctr Clin Vaccinol & Trop Med, Oxford OX3 7LJ, EnglandShoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
White, Nicholas J.
;
Nosten, Francois
论文数: 0引用数: 0
h-index: 0
机构:
Shoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Mahidol Univ, Fac Trop Med, Bangkok 10700, Thailand
Churchill Hosp, Ctr Clin Vaccinol & Trop Med, Oxford OX3 7LJ, EnglandShoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
机构:
Shoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Mahidol Univ, Fac Trop Med, Bangkok 10700, Thailand
Churchill Hosp, Ctr Clin Vaccinol & Trop Med, Oxford OX3 7LJ, EnglandShoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Ashley, Elizabeth A.
;
Stepniewska, Kasia
论文数: 0引用数: 0
h-index: 0
机构:
Mahidol Univ, Fac Trop Med, Bangkok 10700, Thailand
Churchill Hosp, Ctr Clin Vaccinol & Trop Med, Oxford OX3 7LJ, EnglandShoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Stepniewska, Kasia
;
Lindegardh, Niklas
论文数: 0引用数: 0
h-index: 0
机构:
Mahidol Univ, Fac Trop Med, Bangkok 10700, Thailand
Churchill Hosp, Ctr Clin Vaccinol & Trop Med, Oxford OX3 7LJ, EnglandShoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Lindegardh, Niklas
;
McGready, Rose
论文数: 0引用数: 0
h-index: 0
机构:
Shoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Mahidol Univ, Fac Trop Med, Bangkok 10700, Thailand
Churchill Hosp, Ctr Clin Vaccinol & Trop Med, Oxford OX3 7LJ, EnglandShoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
McGready, Rose
;
Annerberg, Anna
论文数: 0引用数: 0
h-index: 0
机构:
Mahidol Univ, Fac Trop Med, Bangkok 10700, ThailandShoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Annerberg, Anna
;
Hutagalung, Robert
论文数: 0引用数: 0
h-index: 0
机构:
Shoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Mahidol Univ, Fac Trop Med, Bangkok 10700, ThailandShoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Hutagalung, Robert
;
Singtoroj, Thida
论文数: 0引用数: 0
h-index: 0
机构:
Mahidol Univ, Fac Trop Med, Bangkok 10700, ThailandShoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Singtoroj, Thida
;
Hla, Gilvary
论文数: 0引用数: 0
h-index: 0
机构:
Shoklo Res Unit, POB 46, Mae Sot 63110, Tak, ThailandShoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Hla, Gilvary
;
Brockman, Al
论文数: 0引用数: 0
h-index: 0
机构:
Shoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Mahidol Univ, Fac Trop Med, Bangkok 10700, Thailand
Churchill Hosp, Ctr Clin Vaccinol & Trop Med, Oxford OX3 7LJ, England
Charles Darwin Univ, Menzies Sch Hlth Res, Darwin, NT, AustraliaShoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Brockman, Al
;
Proux, Stephane
论文数: 0引用数: 0
h-index: 0
机构:
Shoklo Res Unit, POB 46, Mae Sot 63110, Tak, ThailandShoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Proux, Stephane
;
Wilahphaingern, Jahser
论文数: 0引用数: 0
h-index: 0
机构:
Shoklo Res Unit, POB 46, Mae Sot 63110, Tak, ThailandShoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Wilahphaingern, Jahser
;
论文数: 引用数:
h-index:
机构:
Singhasivanon, Pratap
;
White, Nicholas J.
论文数: 0引用数: 0
h-index: 0
机构:
Mahidol Univ, Fac Trop Med, Bangkok 10700, Thailand
Churchill Hosp, Ctr Clin Vaccinol & Trop Med, Oxford OX3 7LJ, EnglandShoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
White, Nicholas J.
;
Nosten, Francois
论文数: 0引用数: 0
h-index: 0
机构:
Shoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand
Mahidol Univ, Fac Trop Med, Bangkok 10700, Thailand
Churchill Hosp, Ctr Clin Vaccinol & Trop Med, Oxford OX3 7LJ, EnglandShoklo Res Unit, POB 46, Mae Sot 63110, Tak, Thailand