γ-Tocotrienol metabolism and antiproliferative effect in prostate cancer cells

被引：49

作者：

Conte, C ^{[1
]}

Floridi, A ^{[1
]}

Aisa, C ^{[1
]}

Piroddi, M ^{[1
]}

Floridi, A ^{[1
]}

Galli, F ^{[1
]}

机构：

[1] Univ Perugia, Dept Internal Med, Sect Appl Biochem & Nutrit Sci, I-06126 Perugia, Italy

来源：

VITAMIN E AND HEALTH | 2004年 / 1031卷

关键词：

vitamin E; tocotrienol; tocopherol; carboxyethyl-hydroxychroman; CEHC; prostate cancer cells; hepatocarcinoma cells; cytochrome P-450;

D O I：

10.1196/annals.1331.054

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, we evaluated the antiproliferative effect of tocotrienols (T3) and the presence of a specific vitamin E metabolism in PC3 and LNCaP prostate cancer cells. These cell lines are able to transform tocopherols (T) and T3 in the corresponding carboxyethyl-hydroxychromans metabolites (CEHCs). The extent of this metabolism and the inhibitory effect on cell growth followed the order of magnitude alpha-T <alpha T3 <gamma-T <gamma-T3. The partial inhibition of gamma-T3 metabolism by ketoconazole did not influence cell proliferation. These early findings may suggest that the transformation of vitamin E to CEHC is mostly a detoxification mechanism useful to maintain the malignant properties of prostate cancer cells.

引用

页码：391 / 394

页数：4

共 4 条

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