An introduction to Toll-like receptors and their possible role in the initiation of labour

被引：68

作者：

Patni, S. ^{[1
]}

Flynn, P.

Wynen, L. P.

Seager, A. L.

Morgan, G.

White, J. O.

Thornton, C. A.

机构：

[1] Birmingham Heartlands Hosp, Dept Obstet & Gynaecol, Birmingham B9 5SS, W Midlands, England

[2] Singleton Hosp, Dept Obstet & Gynaecol, Swansea, W Glam, Wales

[3] Univ Swansea, Sch Med, Inst Life Sci, Swansea, W Glam, Wales

来源：

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 2007年 / 114卷 / 11期

关键词：

cytokines; human; parturition; preterm; toll-like; receptors;

D O I：

10.1111/j.1471-0528.2007.01488.x

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Toll-like receptors (TLR) have emerged as key upstream mediators of inflammation at many tissue sites in humans. Inflammatory processes are involved in the process of parturition suggesting that TLR activity within gestation-associated tissues might have an important role in the initiation and/or maintenance of normal term labour and in various pathological states of pregnancy such as infection-associated preterm labour. Either TLRs or their signalling molecules might be excellent therapeutic targets for prevention of preterm labour.

引用

页码：1326 / 1334

页数：9

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