Preparation of ionic-crosslinked chitosan-based gel beads and effect of reaction conditions on drug release behaviors

被引：55

作者：

Chen, Shilan ^{[1
,2
]}

Liu, Mingzhu ^{[1
,2
]}

Jin, Shuping ^{[1
,2
,3
]}

Wang, Bin ^{[1
,2
]}

机构：

[1] Lanzhou Univ, Dept Chem, Lanzhou 730000, Peoples R China

[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[3] Hexi Univ, Dept Chem, Zhangye 734000, Peoples R China

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2008年 / 349卷 / 1-2期

关键词：

chitosan; trisodium citrate; ionic-crosslink; poly(methacrylic acid); polyelectrolyte complex; drug release;

D O I：

10.1016/j.ijpharm.2007.08.029

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Drug-loaded chitosan (CS) beads were prepared under simple and mild condition using trisodium citrate as ionic crosslinker. The beads were further coated with poly(methacrylic acid) (PMAA) by dipping the beads in PMAA aqueous solution. The surface and cross-section morphology of these beads were observed by scanning electron microscopy and the observation showed that the coating beads had core-shell structure. In vitro release of model drug from these beads obtained under different reaction conditions was investigated in buffer medium (pH 1.8). The results showed that the rapid drug release was restrained by PMAA coating and the optimum conditions for preparing CS-based drug-loaded beads were decided through the effect of reaction conditions on the drug release behaviors. In addition, the drug release mechanism of CS-based drug-loaded beads was analyzed by Peppa's potential equation. According to this study, the ionic-crosslinked CS beads coated by PMAA could serve as suitable candidate for drug site-specific carrier in stomach. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：180 / 187

页数：8

共 29 条

[1]

Release of triamcinolone acetonide from mucoadhesive polymer composed of chitosan and poly(acrylic acid) in vitro [J].