Telomere biology in human aging and aging syndromes

被引：91

作者：

Klapper, W ^{[1
]}

Parwaresch, R ^{[1
]}

Krupp, G ^{[1
]}

机构：

[1] Univ Kiel, Ctr Pathol & Appl Canc Res, Inst Hematopathol, D-24105 Kiel, Germany

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2001年 / 122卷 / 07期

关键词：

ataxia telangiectasia; arteriosclerosis; Bloom syndrome; diabetes; Down syndrome; dyskeratosis congenita; end-replication-problem; Hutchinson-Hilford progeria; osteoporosis; premature aging; senescence; telomerase; telosome; Werner syndrome;

D O I：

10.1016/S0047-6374(01)00223-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Telomeres, the extreme ends of the chromosomes play a key role in the process of cellular aging. Due to the 'end-replication-problem', successive shortening of the telomeres with each cell division results in a mitotic clock and it was shown in vitro that this clock limits the replicative capacity of cell proliferation. Telomerase counteracts telomere erosion and provides some somatic cells an unlimited proliferative potential in vitro. The present views of telomeres and telomerase functions in cellular aging in vitro are presented. Possibilities and limitations in the evaluation of the in vivo impact of telomere erosion on human aging, aging syndromes and age related diseases are reviewed. Unresolved questions, future experimental approaches and emerging therapeutic applications are discussed. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：695 / 712

页数：18

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