Proresorptive actions of FSH and bone loss

被引：28

作者：

Zaidi, Mone ^{[1
]}

Blair, Harry C. ^{[2
,3
]}

Iqbal, Jameel ^{[1
]}

Zhu, Ling Ling ^{[1
]}

Kumar, T. Rajendra ^{[4
]}

Zallone, Alberta ^{[5
]}

Sun, Li ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Div Endocrinol, Mt Sinai Bone Program, New York, NY 10029 USA

[2] Univ Pittsburgh, Dept Pathol, Pittsburgh, PA USA

[3] Univ Pittsburgh, Dept Cell Biol, Pittsburgh, PA USA

[4] Univ Kansas, Med Ctr, Kansas City, MO USA

[5] Univ Bari, I-70121 Bari, Italy

来源：

SKELETAL BIOLOGY AND MEDICINE, PT A: ASPECTS OF BONE MORPHOGENESIS AND REMODELING | 2007年 / 1116卷

关键词：

osteoclast; osteoporosis; hypogonadism;

D O I：

10.1196/annals.1402.056

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

We review studies that propose follicle-stimulating hormone (FSH) as a physiologic stimulator of osteoclastic bone resorption. We hypothesize that, in addition to low estrogen, a rising FSH contributes to the increased bone resorption and bone loss in hypergonadism. This is of particular relevance to the perimenopausal transition, wherein profound bone loss is accompanied by trabecular perforations in the face of high FSH and normal estrogen levels. Potential therapeutic implications include the development of antagonists to both circulating FSH and its osteoclastic receptor.

引用

页码：376 / 382

页数：7

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