Identification of α-dystroglycan as a receptor for lymphocytic choriomeningitis virus and lassa fever virus

被引：535

作者：

Cao, W

Henry, MD

Borrow, P

Yamada, H

Elder, JH

Ravkov, EV

Nichol, ST

Compans, RW

Campbell, KP

Oldstone, MBA

机构：

[1] Scripps Res Inst, Dept Neuropharmacol, Div Virol, La Jolla, CA 92037 USA

[2] Univ Iowa, Coll Med, Dept Phys & Biophys, Howard Hughes Med Inst, Iowa City, IA 52242 USA

[3] Edward Jenner Inst Vaccine Res, Newbury RG20 7NN, Berks, England

[4] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

[5] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA

[6] Ctr Dis Control, Atlanta, GA 30333 USA

来源：

SCIENCE | 1998年 / 282卷 / 5396期

关键词：

D O I：

10.1126/science.282.5396.2079

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A peripheral membrane protein that is interactive with Lymphocytic choriomeningitis virus (LCMV) was purified from cells permissive to infection. Tryptic peptides from this protein were determined to be alpha-dystroglycan (alpha-DG). Several strains of LCMV and other arenaviruses, including Lassa fever virus (LFV), Oliveros, and Mobala, bound to purified alpha-DG protein. Soluble alpha-DG blocked both LCMV and LFV infection. Cells bearing a null mutation of the gene encoding DG were resistant to LCMV infection, and reconstitution of DC expression in null mutant cells restored susceptibility to LCMV infection. Thus, alpha-DG is a cellular receptor for both LCMV and LFV.

引用

页码：2079 / 2081

页数：3

共 24 条

[1] CHARACTERIZATION OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS-BINDING PROTEIN(S) - A CANDIDATE CELLULAR RECEPTOR FOR THE VIRUS [J].