Stromal Cells in Chronic Inflammation and Tertiary Lymphoid Organ Formation

被引：189

作者：

Buckley, Christopher D. ^{[1
,2
]}

Barone, Francesca ^{[1
,2
]}

Nayar, Saba ^{[1
,2
]}

Benezech, Cecile ^{[2
]}

Caamano, Jorge ^{[2
]}

机构：

[1] Univ Birmingham, Res Labs, Queen Elizabeth Hosp, Rheumatol Res Grp,Ctr Translat Inflammat Res, Birmingham B15 2WD, W Midlands, England

[2] Univ Birmingham, Coll Med & Dent Sci, Sch Immun & Infect, Birmingham B15 2TT, W Midlands, England

来源：

ANNUAL REVIEW OF IMMUNOLOGY VOL 33 | 2015年 / 33卷

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

stromal cells; fibroblast; chronic inflammation; persistence; FIBROBLASTIC RETICULAR CELLS; TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; MESENCHYMAL STEM-CELLS; TISSUE-INDUCER CELLS; HIGH ENDOTHELIAL VENULES; LT-BETA-R; RHEUMATOID-ARTHRITIS; T-CELLS; DENDRITIC CELLS;

D O I：

10.1146/annurev-immunol-032713-120252

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Inflammation is an unstable state. It either resolves or persists. Why inflammation persists and the factors that define tissue tropism remain obscure. Increasing evidence suggests that tissue-resident stromal cells not only provide positional memory but also actively regulate the differential accumulation of inflammatory cells within inflamed tissues. Furthermore, at many sites of chronic inflammation, structures that mimic secondary lymphoid tissues are observed, suggesting that chronic inflammation and lymphoid tissue formation share common activation programs. Similarly, blood and lymphatic endothelial cells contribute to tissue homeostasis and disease persistence in chronic inflammation. This review highlights our increasing understanding of the role of stromal cells in inflammation and summarizes the novel immunological role that stromal cells exert in the persistence of inflammatory diseases.

引用

页码：715 / 745

页数：31

共 231 条

[1]

Lymph Node Stromal Cells Negatively Regulate Antigen-Specific CD4+ T Cell Responses [J].