Lipoxins: revelations on resolution

被引：115

作者：

McMahon, B ^{[1
]}

Mitchell, S

Brady, HR

Godson, C

机构：

[1] Mater Misericordiae Hosp, Ctr Mol Inflammat & Vasc Res, Dublin 7, Ireland

[2] Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dept Med & Therapeut, Dublin, Ireland

[3] Dubli Mol Med Ctr, Dublin, Ireland

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2001年 / 22卷 / 08期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0165-6147(00)01771-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Lipoxins (LXs) are endogenously produced eicosanoids typically generated during cell-cell interactions. In this article, the compelling evidence from in vitro and in vivo model systems that LXs actively promote the resolution of inflammation is reviewed. Of particular interest are indications that stable synthetic analogues of LXs and aspirin-triggered 15-epi-LXs can mimic many of the desirable anti-inflammatory, 'pro-resolution' actions of native LXs. Given the enhanced stability and efficacy of these compounds a role as novel anti-inflammatory therapeutics is proposed.

引用

页码：391 / 395

页数：5

共 22 条

[1] Cutting edge:: Lipoxin (LX) A4 and aspirin-triggered 15-Epi-LXA4 block allergen-induced eosinophil trafficking [J].

Bandeira-Melo, C ;

Bozza, PT ;

Diaz, BL ;

Cordeiro, RSB ;

Jose, PJ ;

Martins, MA ;

Serhan, CN .

JOURNAL OF IMMUNOLOGY, 2000, 164 (05) :2267-2271

[2] Activation of lipoxin A4 receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammation [J].

Chiang, N ;

Fierro, IM ;

Gronert, K ;

Serhan, CN .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (07) :1197-1207

[3] Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion [J].

Chiang, N ;

Gronert, K ;

Clish, CB ;

O'Brien, JA ;

Freeman, MW ;

Serhan, CN .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (03) :309-316

[4]

CHRISTOPHE T, 2001, IN PRESS J BIOL CHEM

[5] Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo [J].

Clish, CB ;

O'Brien, JA ;

Gronert, K ;

Stahl, GL ;

Petasis, NA ;

Serhan, CN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (14) :8247-8252

[6] Pathogen-induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A4 analogs [J].

Gewirtz, AT ;

McCormick, B ;

Neish, AS ;

Petasis, NA ;

Gronert, K ;

Serhan, CN ;

Madara, JL .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (09) :1860-1869

[7] Cutting edge: Lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages [J].

Godson, C ;

Mitchell, S ;

Harvey, K ;

Petasis, NA ;

Hogg, N ;

Brady, HR .

JOURNAL OF IMMUNOLOGY, 2000, 164 (04) :1663-1667

[8]

GOH J, IN PRESS J IMMUNOL

[9] Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon γ and inhibits tumor necrosis factor α-induced IL-8 release [J].

Gronert, K ;

Gewirtz, A ;

Madara, JL ;

Serhan, CN .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (08) :1285-1294

[10] Selectivity of recombinant human leukotriene D4, leukotriene B4, and lipoxin A4 receptors with aspirin-triggered 15-epi-LXA4 and regulation of vascular and inflammatory responses [J].

Gronert, K ;

Martinsson-Niskanen, T ;

Ravasi, S ;

Chiang, N ;

Serhan, CN .

AMERICAN JOURNAL OF PATHOLOGY, 2001, 158 (01) :3-9

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