NMDA receptor subunit gating - uncovered

被引：12

作者：

Gibb, AJ ^{[1
]}

机构：

[1] UCL, Dept Pharmacol, London WC1E 6BT, England

来源：

TRENDS IN NEUROSCIENCES | 2004年 / 27卷 / 01期

关键词：

D O I：

10.1016/j.tins.2003.10.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Kinetically distinct contributions of NMDA receptor NR1 and NR2 subunits to channel gating have recently been inferred by Banke and Traynelis from single-channel recordings of recombinant NR1-NR2B receptors. The results suggest a new mechanism for receptor activation that will enhance our insight into excitatory synaptic transmission in the brain. In the post-genomic era, this represents an exciting advance in understanding the relationship between structure and function for this unique class of neurotransmitter receptor.

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页码：7 / 10

页数：4

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