4,5-Dihydro-7,8-dimethoxy-1-phenyl-3H-2,3-benzodiazepin-4-one

被引：8

作者：

Bruno, G

Nicoló, F

Rotondo, A

Gitto, R

Zappalá, M

机构：

[1] Univ Messina, Dipartimento Chim Inorgan Chim Analit & Chim Fis, I-98166 Messina, Italy

[2] Univ Messina, Dipartimento Farmacochim, I-98168 Messina, Italy

来源：

ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY | 2001年 / 57卷

关键词：

D O I：

10.1107/S0108270101011805

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The title compound, C17H16N2O3, is an antagonist for AMPA/kainate receptors. The molecule has its seven-membered oxadiazole ring in a boat conformation. Asymmetry of the two methoxy bond angles is evident, with (Me)O-C-C angles of 115.45 (12) and 124.78 (13)°, and 114.67 (12) and 125.31 (12)°. A centrosymmetric dimer involving the HN-CO moieties, with an N···O distance of 2.876 (2) Å, graph set R22(8), is further linked into chains through methoxy Csp3-H···N hydrogen bonds, with a C···N distance of 3.418 (2) Å.

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页码：1225 / 1227

页数：3

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