Singlet Oxygen Generation by Novel NIR BODIPY Dyes

被引：225

作者：

Awuah, Samuel G. ^{[1
,2
]}

Polreis, Jason ^{[3
]}

Biradar, Vidya ^{[3
]}

You, Youngjae ^{[1
,2
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Pharmaceut Sci, Oklahoma City, OK 73117 USA

[2] Univ Oklahoma, Dept Chem & Biochem, Norman, OK 73019 USA

[3] S Dakota State Univ, Dept Chem & Biochem, Brookings, SD 57007 USA

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 15期

关键词：

PHOTODYNAMIC THERAPY; IN-VITRO; FLUORESCENT; DERIVATIVES; CHEMISTRY;

D O I：

10.1021/ol2014076

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Five novel near-infrared BODIPY dyes were prepared for improved singlet oxygen generation using thiophene and bromine. Theoretical, optical, photostable, and singlet oxygen generation characteristics of these dyes were assessed. Predicted excitation energies by TDDFT calculations were in good agreement (Delta E approximate to 0.06 eV) with experimental data. All five dyes showed both excitation and emission In the NIR range. In particular, two dyes having sulfur and bromine atoms showed efficient singlet oxygen generation with high photostability.

引用

页码：3884 / 3887

页数：4

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