The human erythroid-specific transcription factor EKLF localizes to chromosome 19p13.12-p13.13

被引：11

作者：

vanRee, JH

Roskrow, MA

Becher, AM

McNall, R

Valentine, VA

Jane, SM

Cunningham, JM

机构：

[1] ST JUDE CHILDRENS RES HOSP, DIV EXPT HEMATOL, MEMPHIS, TN 38105 USA

[2] ST JUDE CHILDRENS RES HOSP, DEPT EXPT ONCOL, MEMPHIS, TN 38105 USA

[3] UNIV TENNESSEE, DEPT BIOCHEM, MEMPHIS, TN 38103 USA

[4] UNIV TENNESSEE, DEPT PEDIAT, MEMPHIS, TN 38103 USA

[5] ROYAL MELBOURNE HOSP, ROTARY BONE MARROW RES LABS, PARKVILLE, VIC 3050, AUSTRALIA

来源：

GENOMICS | 1997年 / 39卷 / 03期

关键词：

D O I：

10.1006/geno.1996.4472

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Eryehroid Kruppel-like factor (EKLF) is a trans-acting factor that binds specifically to the beta-globin promoter CACCC box. EKLF is essential for adult erythroid development in mice. We have cloned and sequenced a cDNA encoding the human homologue of this gene, which shares 69% identity with the mEKLF protein. The expression of hEKLF is restricted to fetal Liver and adult bone marrow. The genomic locus of hEKLF was mapped to chromosomal band 19p13.12p13.13, using fluorescence in situ hybridization. (C) 1997 Academic Press.

引用

页码：393 / 395

页数：3

共 12 条

[1]

CHAN FKM, 1995, MOL CELL BIOL, V15, P2682

[2]

CUNNINGHAM JM, 1996, SEMIN HEMATOL, V33, P1

[3] ROLE OF ERYTHROID KRUPPEL-LIKE FACTOR IN HUMAN GAMMA-GLOBIN TO BETA-GLOBIN GENE SWITCHING [J].