Alstilobanines A-E, new indole alkaloids from Alstonia angustiloba

被引：46

作者：

Koyama, Koichiro ^{[1
]}

Hirasawa, Yusuke ^{[1
]}

Zaima, Kazumasa ^{[1
]}

Hoe, Teh Chin ^{[2
]}

Chan, Kit-Lam ^{[2
]}

Morita, Hiroshi ^{[1
]}

机构：

[1] Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan

[2] Univ Sains Malaysia, Sch Pharmaceut Sci, George Town 11800, Malaysia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2008年 / 16卷 / 13期

关键词：

alkaloids; Alstonia angustiloba; alstilobanines A-E; vasorelaxant activity;

D O I：

10.1016/j.bmc.2008.05.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Five new alkaloids, alstilobanines A (1)-E (5) were isolated from Alstonia angustiloba (Apocynaceae) and their structures were determined by MS and 2D NMR spectral analysis. Alstilobanines A-E showed a moderate vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：6483 / 6488

页数：6

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