The role of glial adenosine receptors in neural resilience and the neurobiology of mood disorders

被引:62
作者
Calker, D
Biber, K
机构
[1] Univ Freiburg, Dept Psychiat & Psychotherapy, D-79104 Freiburg, Germany
[2] Univ Groningen, Dept Med Physiol, Groningen, Netherlands
关键词
adenosine receptors; astrocytes; depression; electroconvulsive therapy; interleukin-6; sleep deprivation;
D O I
10.1007/s11064-005-8792-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Adenosine receptors were classified into A(1)- and A(2)-receptors in the laboratory of Bernd Hamprecht more than 25 years ago. Adenosine receptors are instrumental to the neurotrophic effects of glia cells. Both microglia and astrocytes release after stimulation via adenosine receptors factors that are important for neuronal survival and growth. Neuronal resilience is now considered as of pivotal importance in the neurobiology of mood disorders and their treatment. Both sleep deprivation and electroconvulsive therapy, two effective therapeutic measures in mood disorders, are associated with an increase of adenosine and upregulation of adenosine A(1)-receptors in the brain. Parameters closely related to adenosine receptor activation such as cerebral metabolic rate and delta power in the sleep EEG provide indirect evidence that adenosinergic signaling may be associated with the therapeutic response to these measures. Thus, neurotrophic effects evoked by adenosine receptors might be important in the mechanism of action of ECT and perhaps also sleep deprivation.
引用
收藏
页码:1205 / 1217
页数:13
相关论文
共 187 条
[1]   MODULATION OF ASTROGLIAL CELL-PROLIFERATION BY ANALOGS OF ADENOSINE AND ATP IN PRIMARY CULTURES OF RAT STRIATUM [J].
ABBRACCHIO, MP ;
SAFFREY, MJ ;
HOPKER, V ;
BURNSTOCK, G .
NEUROSCIENCE, 1994, 59 (01) :67-76
[2]   Modulation of apoptosis by adenosine in the central nervous system: a possible role for the A(3) receptor - Pathophysiological significance and therapeutic implications for neurodegenerative disorders [J].
Abbracchio, MP ;
Ceruti, S ;
Brambilla, R ;
Franceschi, C ;
Malorni, W ;
Jacobson, KA ;
vonLubitz, DKJE ;
Cattabeni, F .
NEUROPROTECTIVE AGENTS - THIRD INTERNATIONAL CONFERENCE, 1997, 825 :11-22
[3]   Electroconvulsive seizures regulate gene expression of distinct neurotrophic signaling pathways [J].
Altar, CA ;
Laeng, P ;
Jurata, LW ;
Brockman, JA ;
Lemire, A ;
Bullard, J ;
Bukhman, YV ;
Young, TA ;
Charles, V ;
Palfreyman, MG .
JOURNAL OF NEUROSCIENCE, 2004, 24 (11) :2667-2677
[4]   Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain [J].
Altar, CA ;
Whitehead, RE ;
Chen, RY ;
Wörtwein, G ;
Madsen, TM .
BIOLOGICAL PSYCHIATRY, 2003, 54 (07) :703-709
[5]   UP-REGULATION OF A1 ADENOSINE RECEPTORS IN HUMAN TEMPORAL-LOBE EPILEPSY - A QUANTITATIVE AUTORADIOGRAPHIC STUDY [J].
ANGELATOU, F ;
PAGONOPOULOU, O ;
MARAZIOTIS, T ;
OLIVIER, A ;
VILLEMEURE, JG ;
AVOLI, M ;
KOSTOPOULOS, G .
NEUROSCIENCE LETTERS, 1993, 163 (01) :11-14
[6]   Neurotrophic factors and CNS disorders:: findings in rodent models of depression and schizophrenia [J].
Angelucci, F ;
Mathé, AA ;
Aloe, L .
NGF AND RELATED MOLECULES IN HEALTH AND DISEASE, 2004, 146 :151-165
[7]   Glial cells in neurotoxicity development [J].
Aschner, M ;
Allen, JW ;
Kimelberg, HK ;
LoPachin, RM ;
Streit, WJ .
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1999, 39 :151-173
[8]   CYTOTOXICITY OF MICROGLIA [J].
BANATI, RB ;
GEHRMANN, J ;
SCHUBERT, P ;
KREUTZBERG, GW .
GLIA, 1993, 7 (01) :111-118
[9]  
BARGER SW, 1992, J BIOL CHEM, V267, P9689
[10]   Adenosine and sleep-wake regulation [J].
Basheer, R ;
Strecker, RE ;
Thakkar, MM ;
McCarley, RW .
PROGRESS IN NEUROBIOLOGY, 2004, 73 (06) :379-396