NEDD4: The founding member of a family of ubiquitin-protein ligases

被引：153

作者：

Boase, Natasha Anne ^{[1
]}

Kumar, Sharad ^{[1
]}

机构：

[1] Univ S Australia, Ctr Canc Biol, Adelaide, SA 5001, Australia

来源：

GENE | 2015年 / 557卷 / 02期

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

Ubiquitin; Ubiquitin protein ligases; NEDD4; family; IGF signalling; PTEN; GROWTH-FACTOR RECEPTOR; FACTOR-I RECEPTOR; E3; LIGASE; WW DOMAIN; EPITHELIAL NA+; C2; DOMAIN; MEDIATED DEGRADATION; FUNCTIONAL DIVERSITY; TUMOR-SUPPRESSOR; IRON HOMEOSTASIS;

D O I：

10.1016/j.gene.2014.12.020

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

Ubiquitination plays a crucial role in regulating proteins post-translationally. The focus of this review is on NEDD4, the founding member of the NEDD4 family of ubiquitin ligases that is evolutionarily conserved in eukaryotes. Many potential substrates of NEDD4 have been identified and NEDD4 has been shown to play a critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumour suppressor PTEN. In this review we will discuss the diverse pathways in which NEDD4 is involved, and the pathophysiological significance of this important ubiquitin ligase. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：113 / 122

页数：10

共 121 条

[1]

The Cyclin-dependent Kinase Activator, Spy1A, Is Targeted for Degradation by the Ubiquitin Ligase NEDD4 [J].

Al Sorkhy, Mohammad ;

Craig, Ryan ;

Market, Brenna ;

Ard, Ryan ;

Porter, Lisa A. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (05) :2617-2627

[2]

Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes [J].

Anan, T ;

Nagata, Y ;

Koga, H ;

Honda, Y ;

Yabuki, N ;

Miyamoto, C ;

Kuwano, A ;

Matsuda, I ;

Endo, F ;

Saya, H ;

Nakao, M .

GENES TO CELLS, 1998, 3 (11) :751-763

[3]

Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1 [J].

Anindya, Roy ;

Ayguen, Ozan ;

Svejstrup, Jesper Q. .

MOLECULAR CELL, 2007, 28 (03) :386-397

[4]

The Antiproliferative Response of Indole-3-Carbinol in Human Melanoma Cells Is Triggered by an Interaction with NEDD4-1 and Disruption of Wild-Type PTEN Degradation [J].

Aronchik, Ida ;

Kundu, Aishwarya ;

Quirit, Jeanne G. ;

Firestone, Gary L. .

MOLECULAR CANCER RESEARCH, 2014, 12 (11) :1621-1634

[5]

Respiratory distress and perinatal lethality in Nedd4-2-deficient mice [J].

Boase, Natasha A. ;

Rychkov, Grigori Y. ;

Townley, Scott L. ;

Dinudom, Anuwat ;

Candi, Eleanora ;

Voss, Anne K. ;

Tsoutsman, Tatiana ;

Semsarian, Chris ;

Melino, Gerry ;

Koentgen, Frank ;

Cook, David I. ;

Kumar, Sharad .

NATURE COMMUNICATIONS, 2011, 2

[6]

THE WW DOMAIN - A SIGNALING SITE IN DYSTROPHIN [J].

BORK, P ;

SUDOL, M .

TRENDS IN BIOCHEMICAL SCIENCES, 1994, 19 (12) :531-533

[7]

Subtle gait abnormalities in Nedd4 heterozygous mice [J].

Camera, Daria ;

Boase, Natasha A. ;

Kumar, Sharad ;

Pow, David V. ;

Poronnik, Philip .

BEHAVIOURAL BRAIN RESEARCH, 2014, 260 :15-24

[8]

Nedd4 Controls Animal Growth by Regulating IGF-1 Signaling [J].

Cao, Xiao R. ;

Lill, Nancy L. ;

Boase, Natasha ;

Shi, Peijun P. ;

Croucher, David R. ;

Shan, Hongbo ;

Qu, Jing ;

Sweezer, Eileen M. ;

Place, Trenton ;

Kirby, Patricia A. ;

Daly, Roger J. ;

Kumar, Sharad ;

Yang, Baoli .

SCIENCE SIGNALING, 2008, 1 (38)

[9]

The Nedd4-like family of E3 ubiquitin ligases and cancer [J].

Chen, Ceshi ;

Matesic, Lydia E. .

CANCER AND METASTASIS REVIEWS, 2007, 26 (3-4) :587-604

[10]

Disruption of E3 ligase NEDD4 in peripheral neurons interrupts axon outgrowth: Linkage to PTEN [J].

Christie, Kimberly J. ;

Martinez, Jose A. ;

Zochodne, Douglas W. .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2012, 50 (02) :179-192

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