Lack of effect of the cytokine suppressive agent FR167653 on tumour growth and cachexia in rats bearing the Yoshida AH-130 ascites hepatoma

被引：4

作者：

Busquets, S ^{[1
]}

Alvarez, B ^{[1
]}

van Royen, M ^{[1
]}

Carbó, N ^{[1
]}

López-Soriano, FJ ^{[1
]}

Argilés, JM ^{[1
]}

机构：

[1] Univ Barcelona, Dept Bioquim & Biol Mol, E-08028 Barcelona, Spain

来源：

CANCER LETTERS | 2000年 / 157卷 / 01期

关键词：

tumour necrosis factor-alpha; interleukin-1; cancer cachexia;

D O I：

10.1016/S0304-3835(00)00476-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Daily s.c. administration of 6 mg/kg of FR167653 tan inhibitor of the synthesis of interleukin-l and tumour necrosis factor-or) to rats bearing the ascites hepatoma Yoshida AH-130 (a highly cachectic tumour) did not prevent either the anorexia or the massive weight loss - affecting both adipose tissue and skeletal muscle - present in the cachectic animals. The compound did not affect the circulating revels of triacylglycerols or other metabolites such as glucose or lactate. Nor did the administration of FR167653 influence tumour growth. It is concluded that the drug is unable to reverse the cachectic state in this particular experimental tumour model. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：99 / 103

页数：5

共 35 条

[1]

ADAMS R, 1981, PRINCIPLES NEUROLOGY, P341

[2] THE ROLE OF CYTOKINES IN MUSCLE WASTING - ITS RELATION WITH CANCER CACHEXIA [J].

ARGILES, JM ;

GARCIAMARTINEZ, C ;

LLOVERA, M ;

LOPEZSORIANO, FJ .

MEDICINAL RESEARCH REVIEWS, 1992, 12 (06) :637-652

[3]

ARGILES JM, 1988, MOL CELL BIOCHEM, V81, P3

[4]

Argiles JM, 1997, MED RES REV, V17, P477, DOI 10.1002/(SICI)1098-1128(199709)17:5<477::AID-MED3>3.3.CO

[5]

2-Q

[6]

ARGILES JM, 1998, CURR OPIN CLIN NUTR, V1, P241

[7]

BADGER AM, 1994, CIRC SHOCK, V44, P188

[8]

Balazs C, 1994, Acta Microbiol Immunol Hung, V41, P121

[9] PENTOXIFYLLINE DECREASES BODY-WEIGHT LOSS AND MUSCLE PROTEIN WASTING CHARACTERISTICS OF SEPSIS [J].

BREUILLE, D ;

FARGE, MC ;

ROSE, F ;

ARNAL, M ;

ATTAIX, D ;

OBLED, C .

AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 265 (04) :E660-E666

[10] Manipulation of the ubiquitin-proteasome pathway in cachexia:: pentoxifylline suppresses the activation of 20S and 26S proteasomes in muscles from tumor-bearing rats [J].

Combaret, L ;

Rallière, C ;

Taillandier, D ;

Tanaka, K ;

Attaix, D .

MOLECULAR BIOLOGY REPORTS, 1999, 26 (1-2) :95-101

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