Splenic blood flow and fluid efflux from the intravascular space in the rat

被引:24
作者
Chen, A [1 ]
Kaufman, S [1 ]
机构
[1] UNIV ALBERTA,DEPT MED,EDMONTON,AB T6G 2S2,CANADA
来源
JOURNAL OF PHYSIOLOGY-LONDON | 1996年 / 490卷 / 02期
关键词
D O I
10.1113/jphysiol.1996.sp021160
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
1. Previous evidence has suggested that fluid is extracted from the blood during its passage through the splenic circulation. In order to further investigate this phenomenon, flow probes were placed around the splenic artery and vein of rats. Splenic blood flow and mean arterial blood pressure were measured immediately after surgery while the rats were still anaesthetized. Five days later, the measurements were repeated first in conscious rats, and then after administering sodium pentobarbitone. Final measurements were made in the conscious animals at day 10 post surgery. 2. Splenic arterial blood flow was lowest at the time of surgery It had doubled by day 5, and remained stable thereafter at about 8 ml min(-1). Splenic venous blood flow also increased after surgery: but less so than the arterial flow, so that the arteriovenous difference had increased to 2.0 +/- 0.4 ml min(-1) by day 5. 3. In response to sodium pentobarbitone (20 mg I.V.), there mas a transient fall in splenic arterial blood flow from 6.7 +/- 0.9 to 4.9 +/- 0.7 ml min(-1). There was no significant change in the arteriovenous difference of blood flow. 4. In conclusion, we have shown that splenic blood flow is considerably higher than previously reported. We have also revealed a significant new path for fluid efflux from the intravascular space; at least 25% of fluid volume flowing into tile spleen is removed from the circulating blood. 5. Although anaesthesia modulates splenic blood flow the changes are not as pronounced as those observed in the acute surgically prepared animal.
引用
收藏
页码:493 / 499
页数:7
相关论文
共 15 条
[1]   A RAPID AND POTENT NATRIURETIC RESPONSE TO INTRAVENOUS-INJECTION OF ATRIAL MYOCARDIAL EXTRACT IN RATS [J].
DEBOLD, AJ ;
BORENSTEIN, HB ;
VERESS, AT ;
SONNENBERG, H .
LIFE SCIENCES, 1981, 28 (01) :89-94
[2]  
FLAIM SF, 1982, J PHARMACOL EXP THER, V222, P359
[3]  
GROSS DR, 1985, ANIMAL MODELS CARDIO, P398
[4]   The adult anatomy of the lymphatic system in the common rat (epimys norvegicus) [J].
Job, TT .
ANATOMICAL RECORD, 1915, 9 (06) :447-458
[5]   SPLENIC CONTROL OF INTRAVASCULAR VOLUME IN THE RAT [J].
KAUFMAN, S ;
DENG, YM .
JOURNAL OF PHYSIOLOGY-LONDON, 1993, 468 :557-565
[6]   ROLE OF SPLEEN IN ANF-INDUCED REDUCTION IN PLASMA-VOLUME [J].
KAUFMAN, S .
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1992, 70 (08) :1104-1108
[7]   EFFECT OF ELECTROLYTES ON FORMATION OF INTESTINAL LYMPH IN RATS [J].
KIM, KS ;
BOLLMAN, JL .
AMERICAN JOURNAL OF PHYSIOLOGY, 1954, 179 (02) :273-278
[8]  
KOSHIKAWA T, 1984, ACTA PATHOL JAPON, V34, P1301
[9]   FAST TRANSIT OF RED-CELLS AND PLASMA IN CONTRACTED VERSUS RELAXED SPLEENS [J].
LEVESQUE, MJ ;
GROOM, AC .
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1981, 59 (01) :53-58
[10]   EFFECTS OF SURGERY ON PLASMA-VOLUME AND SALT AND WATER-EXCRETION IN RATS [J].
MADDOX, DA ;
PRICE, DC ;
RECTOR, FC .
AMERICAN JOURNAL OF PHYSIOLOGY, 1977, 233 (06) :F600-F606