Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema

被引：145

作者：

Igarashi, Hironaka ^{[1
]}

Huber, Vincent J. ^{[1
]}

Tsujita, Mika ^{[1
]}

Nakada, Tsutomu ^{[1
]}

机构：

[1] Niigata Univ, Brain Res Inst, Ctr Integrated Human Brain Sci, Chuoh Ku, Niigata 9518585, Japan

来源：

NEUROLOGICAL SCIENCES | 2011年 / 32卷 / 01期

关键词：

Aquaporin; 4; Brain ischemia; Brain edema; Magnetic resonance imaging; BRAIN EDEMA; IDENTIFICATION; EXPRESSION; RELEASE; SPACE;

D O I：

10.1007/s10072-010-0431-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

We investigated the in vivo effects of a novel aquaporin 4 (AQP4) inhibitor 2-(nicotinamide)-1,3,4-thiadiazole, TGN-020, in a mouse model of focal cerebral ischemia using 7.0-T magnetic resonance imaging (MRI). Pretreatment with TGN-020 significantly reduced brain edema associated with brain ischemia, as reflected by percentage of brain swelling volume (%BSV), 12.1 +/- A 6.3% in the treated group, compared to (20.8 +/- A 5.9%) in the control group (p < 0.05), and in the size of cortical infarction as reflected by the percentage of hemispheric lesion volume (%HLV), 20.0 +/- A 7.6% in the treated group, compared to 30.0 +/- A 9.1% in the control group (p < 0.05). The study indicated the potential pharmacological use of AQP4 inhibition in reducing brain edema associated with focal ischemia.

引用

页码：113 / 116

页数：4

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