Intercedensides D-I, cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens Lampert

被引：42

作者：

Zou, ZR

Yi, YH

Wu, HM

Yao, XS

Du, LJ

Wu, JH

Liaw, CC

Lee, KH

机构：

[1] Second Mil Med Univ, Sch Pharm, Res Ctr Marine Drugs, Shanghai 200433, Peoples R China

[2] Tsinghua Univ, Postdoctoral Stn Biol, Beijing 100084, Peoples R China

[3] RITS, Postdoctoral Res Workstn, Shenzhen 518057, Peoples R China

[4] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

[5] 306 Hosp, Dept Pharm, Beijing 100101, Peoples R China

[6] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 04期

关键词：

D O I：

10.1021/np040205b

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Six new triterpene glycosides, intercedensides D-I (1-6), were isolated from the whole bodies of the sea cucumber Mensamria intercedens Lampert, which is found in the South China Sea. Their structures were elucidated by extensive spectroscopic analysis (NMR and ESIMS) and chemical methods. Intercedensides D (1), E (2), G (4), and H (5) have a conjugated double bond system (22Z,24-diene) in the aglycon side chain, while intercedensides F (3) and 1 (6) have only a single double bond (24, 25) in this same chain. Intercedensides D-H (1-5) showed significant cytotoxicity (ED50 0.96-5.0 mu g/mL) against 10 human tumor cell lines.

引用

页码：540 / 546

页数：7

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