Functionalized gold nanoparticles mimic catalytic activity of a polysiloxane-synthesizing enzyme

被引：74

作者：

Kisailus, D

Najarian, M

Weaver, JC

Morse, DE ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Inst Collaborat Biotechnol, Santa Barbara, CA 93106 USA

[2] Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA

[3] Univ Calif Santa Barbara, Calif NanoSyst Inst, Santa Barbara, CA 93106 USA

[4] Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA

来源：

ADVANCED MATERIALS | 2005年 / 17卷 / 10期

关键词：

D O I：

10.1002/adma.200401109

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A synthetic analogue of a naturally occurring enzyme has been produced by grafting appropriate nucleophilic and hydrogen-bonding functionalities to gold nanoparticles via self-assembled monolayers (see Figure and cover). The synthetic analogue mimics silicatein proteins, which act as both catalysts and templates for formation of silica needles in a marine sponge, converting silicon alkoxide precursors to silica at low temperatures and near-neutral pH.

引用

页码：1234 / +

页数：7

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[1] Less is more in medicine - Sophisticated forms of nanotechnology will find some of their first real-world applications in biomedical research, disease diagnosis and, possibly, therapy [J].