Regulation of the mitogen-activated protein kinases by Brucella spp. expressing a smooth and rough phenotype:: Relationship to pathogen invasiveness

被引：28

作者：

de Bagüés, MPJ

Gross, A

Terraza, A

Dornand, J

机构：

[1] Ctr Invest & Tecnol Agroalimentaria Aragon, Zaragoza 50080, Spain

[2] Univ Montpellier 2, INSERM, U 431, F-34095 Montpellier, France

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 05期

关键词：

D O I：

10.1128/IAI.73.5.3178-3183.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

By comparing smooth wild-type Brucella spp. to their rough mutants, we show that the LPS O chain restricted the activation of the ERK1/2 and p38 mitogen-activated protein kinase (MAPK) pathways, thus preventing the synthesis of immune mediators that regulate host defense. We conclude that the MAPKs are a target for immune intervention by virulent smooth Brucella.

引用

收藏

页码：3178 / 3183

页数：6

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