Novel microfluidic mixer utilizing electrokinetic driving forces under low switching frequency

被引:64
作者
Fu, LM
Yang, RJ
Lin, CH [1 ]
Chien, YS
机构
[1] Natl Sun Yat Sen Univ, Dept Mech & Electromech Engn, Kaohsiung 804, Taiwan
[2] Natl Sun Yat Sen Univ, Ctr Nanosci & Nanotechnol, Kaohsiung 804, Taiwan
[3] Natl Pingtung Univ Sci & Technol, Grad Inst Mat Engn, Pingtung, Taiwan
[4] Natl Cheng Kung Univ, Dept Engn Sci, Tainan 70101, Taiwan
关键词
double-T-form microfluidic mixer; miniaturization; periodic electrokinetic driving;
D O I
10.1002/elps.200410222
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
This paper presents a novel technique in which low-frequency periodic electrokinetic driving forces are utilized to mix electrolytic fluid samples rapidly and efficiently in a double-T-form microfluidic mixer. Without using any additional equipment to induce flow perturbations, only a single high-voltage power source is required for simultaneously driving and mixing the sample fluids which results in a simple and low-cost system for the mixing purpose. The effectiveness of the mixer as a function of the applied electric field and the periodic switching frequency is characterized by the intensity distribution calculated downstream from the mixing zone. The present numerical and experimental results confirm that the proposed double-T-form micromixer has excellent mixing capabilities. The mixing efficiency can be as high as 95% within a mixing length of 1000 mu m downstream from the secondary T-junction when a 100 V/cm driving electric field strength and a 2 Hz periodic switching frequency are applied. The results reveal that the optimal switching frequency depends upon the magnitude of the main applied electrical field. The rapid double-T-form microfluidic mixer using the periodic driving voltage switching model proposed in this study has considerable potential for use in lab-on-a-chip systems.
引用
收藏
页码:1814 / 1824
页数:11
相关论文
共 57 条
[1]  
AHU X, 1998, SENSOR ACTUAT A-PHYS, V66, P355
[2]   Microfluidic separation of DNA [J].
Ashton, R ;
Padala, C ;
Kane, RS .
CURRENT OPINION IN BIOTECHNOLOGY, 2003, 14 (05) :497-504
[3]  
Beebe D J, 2001, MEC IND, V2, P343
[4]   Microstructure for efficient continuous flow mixing [J].
Bessoth, FG ;
deMello, AJ ;
Manz, A .
ANALYTICAL COMMUNICATIONS, 1999, 36 (06) :213-215
[5]   Generation of gradients having complex shapes using microfluidic networks [J].
Dertinger, SKW ;
Chiu, DT ;
Jeon, NL ;
Whitesides, GM .
ANALYTICAL CHEMISTRY, 2001, 73 (06) :1240-1246
[6]   An example of a chaotic micromixer: the cross-channel micromixer [J].
Dodge, A ;
Jullien, MC ;
Lee, YK ;
Niu, X ;
Okkels, F ;
Tabeling, P .
COMPTES RENDUS PHYSIQUE, 2004, 5 (05) :557-563
[7]   TIMESCALES OF TRANSIENT PROCESSES IN CAPILLARY ELECTROPHORESIS [J].
DOSE, EV ;
GUIOCHON, G .
JOURNAL OF CHROMATOGRAPHY A, 1993, 652 (01) :263-275
[8]   Characterization of mixing in micromixers by a test reaction:: Single mixing units and mixer arrays [J].
Ehrfeld, W ;
Golbig, K ;
Hessel, V ;
Löwe, H ;
Richter, T .
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 1999, 38 (03) :1075-1082
[9]   Influence of surface heterogeneity on electrokinetically driven microfluidic mixing [J].
Erickson, D ;
Li, DQ .
LANGMUIR, 2002, 18 (05) :1883-1892
[10]   Analysis of electroosmotic flow with step change in zeta potential [J].
Fu, LM ;
Lin, JY ;
Yang, RJ .
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2003, 258 (02) :266-275