Cell contact dependent extended release of adenovirus by microparticles in vitro

被引：13

作者：

Cavanagh, HMA

Dingwall, D

Steel, J

Benson, J

Burton, M

机构：

[1] Charles Sturt Univ, Sch Biomed Sci, Wagga Wagga, NSW 2678, Australia

[2] Polygenet Inc, Los Gatos, CA 95032 USA

来源：

JOURNAL OF VIROLOGICAL METHODS | 2001年 / 95卷 / 1-2期

关键词：

adenovirus; gene transfer; microparticle complexing;

D O I：

10.1016/S0166-0934(01)00291-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Adenoviral vectors remain one of the most promising methods of gene delivery but are plagued by several inherent problems including immune inactivation and transient expression. This paper reports a novel microparticle-based delivery system for adenovirus that allows high uptake of virus, stable complex formation and extended release. In addition. this microparticle/adenovirus complex has been demonstrated to only release virus upon cell contact. The significant clinical implications of this delivery system are discussed. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：57 / 64

页数：8

共 16 条

[1] Poly(lactic-glycolic) acid copolymer encapsulation of recombinant adenovirus reduces immunogenicity in vivo [J].