Diazepam and nicotine increase social interaction in gerbils: a test for anxiolytic action

被引:34
作者
File, SE [1 ]
Cheeta, S [1 ]
Akanezi, C [1 ]
机构
[1] Kings Coll London, GKT Sch Biomed Sci, Ctr Neurosci, Psychopharmacol Res Unit, London SE1 1UL, England
关键词
anxiety; benzodiazepines; nicotine;
D O I
10.1016/S0006-8993(00)03102-4
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effects of two drugs with anxiolytic actions, diazepam (0.1, 0.3 and 1 mg/kg) and nicotine (0.1 and 0.5 mg/kg) were examined on the time spent in social interaction by pairs of male gerbils. In a test arena lit by high tight, diazepam (0.1 mg/k.g) increased social interaction, without changing locomotor activity. Diazepam (0.3 and 1 mg/kg) produced a dose-related increase in locomotor activity, which reached significance at the higher dose. Nicotine produced a dose-related increase in social interaction, which reached significance at 0.5 mg/kg, but was without effect on locomotor activity. The specific increases in social interaction observed with diazepam and nicotine are similar to those seen in the well-validated social interaction test of anxiety in rats and suggest that social interaction in gerbils may also be used to screen for anxiolytic action of novel compounds. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:311 / 313
页数:3
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